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      Clinical Value of Vitamin D, Trace Elements, Glucose, and Lipid Metabolism in Diagnosis and Severity Evaluation of Psoriasis

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          Abstract

          Objective

          The levels of vitamin D, trace elements, and glucose and lipid metabolism in psoriasis were evaluated, and their value in disease diagnosis and severity evaluation was explored.

          Methods

          In this study, the serum trace elements, blood glucose, and blood lipid indexes of 360 patients with psoriasis and 500 healthy subjects were compared and analyzed.

          Results

          The results of 25-(OH) D3, Cu/Zn, and HDL-C in patients with psoriasis were significantly different from those in the control group. With the aggravation of the disease, Psoriasis Area and Severity Index (PASI) was positively correlated with 25-(OH) D3 and HDL-C and negatively correlated with Cu/Zn. The AUC of the three indexes for the diagnosis of psoriasis was 0.899, 0.675, and 0.848, respectively.

          Conclusion

          There are metabolic abnormalities of 25-(OH) D3, Cu/Zn, and HDL-C in patients with psoriasis, and paying attention to these indicators is conducive to the diagnosis of disease.

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          Most cited references23

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          Role of Minerals and Trace Elements in Diabetes and Insulin Resistance

          Pallavi Dubey, Vikram Thakur, Munmun Chattopadhyay (2020)
          Minerals and trace elements are micronutrients that are essential to the human body but present only in traceable amounts. Nonetheless, they exhibit well-defined biochemical functions. Deficiencies in these micronutrients are related to widespread human health problems. This review article is focused on some of these minerals and trace element deficiencies and their consequences in diabetes and insulin resistance. The levels of trace elements vary considerably among different populations, contingent on the composition of the diet. In several Asian countries, large proportions of the population are affected by a number of micronutrient deficiencies. Local differences in selenium, zinc, copper, iron, chromium and iodine in the diet occur in both developed and developing countries, largely due to malnutrition and dependence on indigenous nutrition. These overall deficiencies and, in a few cases, excess of essential trace elements may lead to imbalances in glucose homeostasis and insulin resistance. The most extensive problems affecting one billion people or more worldwide are associated with inadequate supply of a number of minerals and trace elements including iodine, selenium, zinc, calcium, chromium, cobalt, iron, boron and magnesium. This review comprises various randomized controlled trials, cohort and case-controlled studies, and observational and laboratory-based studies with substantial outcomes of micronutrient deficiencies on diabetes and insulin resistance in diverse racial inhabitants from parts of Asia, Africa, and North America. Changes in these micronutrient levels in the serum and urine of subjects may indicate the trajectory toward metabolic changes, oxidative stress and provide disease-relevant information.
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            The association between psoriasis and dyslipidaemia: a systematic review.

            Richard J E Armstrong, Jane Y C Ma, Caitlin Harskamp … (2013)
            Psoriasis may be associated with dyslipidaemia, a known risk factor for cardiovascular disease. This systematic review aims to synthesize evidence for the association between psoriasis and dyslipidaemia. Through a systematic search using MEDLINE, Embase and the Cochrane Central Register, from 1 January 1980 to 1 January 2012, we identified 25 observational studies that met the inclusion criteria. These 25 studies included over 2·4 million participants, among whom 265,512 were patients with psoriasis. Twenty studies (80%) reported that psoriasis was significantly associated with dyslipidaemia, with odds ratios (ORs) for dyslipidaemia ranging from 1·04 to 5·55 in 238,385 patients with psoriasis, from a population of 2,340,605 participants. Specifically, four studies defining dyslipidaemia as triglyceride levels ≥ 150 mg dL reported significantly increased ORs of 1·20-4·98 for hypertriglyceridaemia in psoriasis. Three studies found that patients with psoriasis presented with significantly increased ORs (1·36-1·77) for high-density lipoprotein cholesterol levels < 40 mg dL , and two studies found hyperlipoproteinaemia to be significantly elevated in patients with psoriasis (ORs 1·55 and 2·09). One cohort study found a significantly higher incidence of hyperlipidaemia among patients with psoriasis (hazard ratio 1·17; 95% confidence interval 1·11-1·23). Among studies that assessed the severity of psoriasis, in 2662 patients with mild psoriasis and 810 patients with severe psoriasis, higher odds of dyslipidaemia were seen in patients with severe psoriasis. Five of the 25 studies (20%) in our review did not show any significant relationship between psoriasis and dyslipidaemia. This systematic review found that psoriasis was significantly associated with greater odds and incidence of dyslipidaemia. Greater psoriasis severity appeared to be associated with higher prevalence of dyslipidaemia. © 2012 The Authors. BJD © 2012 British Association of Dermatologists.
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              Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

              Meenakshi Umar, Konduru S. Sastry, Fatima Al Ali … (2018)
              Background: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis. Methods: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like “vitamin D,” “skin,” “atopic dermatitis,” and “psoriasis.” Only articles published in English and related to the study topic were included in this review. Results: Vitamin D is integrally connected to the skin for its synthesis, metabolism, and activity. It regulates many physiological processes in the skin ranging from cellular proliferation, differentiation, and apoptosis to barrier maintenance and immune functions. Vitamin D deficiency is associated with the risk of psoriasis and atopic dermatitis, and several clinical/observational studies have suggested the beneficial effect of vitamin D in the therapy of these 2 inflammatory skin disorders. Conclusions: Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.
              Article 0 comments Cited 55 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Jihua Zhuang:
                ORCID: https://orcid.org/0000-0003-1904-4743
                Journal
                Journal ID (nlm-ta): Comput Math Methods Med
                Journal ID (iso-abbrev): Comput Math Methods Med
                Journal ID (publisher-id): cmmm
                Title: Computational and Mathematical Methods in Medicine
                Publisher: Hindawi
                ISSN (Print): 1748-670X
                ISSN (Electronic): 1748-6718
                Publication date Collection: 2022
                Publication date (Electronic): 14 July 2022
                Volume: 2022
                Electronic Location Identifier: 8622435
                Affiliations
                1Department of Dermatology, Wujin Hospital Affiliated with Jiangsu University, Changzhou, 213000, China
                2The Wujin Clinical College of Xuzhou Medical University, Changzhou, 213000, China
                3Department of Dermatology, Anxi County Hospital of Fujian Province, Quanzhou 362499, China
                4Department of Dermatology, Taicang Traditional Chinese Medicine Hospital, Suzhou, 215499, China
                5Department of Laboratory, The First People's Hospital of Changzhou, Changzhou, 213004, China
                Author notes

                Academic Editor: Ahmed Faeq Hussein

                Author information
                https://orcid.org/0000-0003-1904-4743
                Article
                DOI: 10.1155/2022/8622435
                PMC ID: 9303117
                PubMed ID: 35872934
                SO-VID: 39319c4b-bec3-4760-ae9a-b99fa4c0d6a0
                Copyright © Copyright © 2022 Da Huang et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 17 May 2022
                Date revision received : 21 June 2022
                Date accepted : 25 June 2022
                Categories
                Subject: Research Article

                ScienceOpen disciplines: Applied mathematics
                Data availability:
                ScienceOpen disciplines: Applied mathematics

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