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      Monitoring of concordance in growth hormone therapy.

      Archives of Disease in Childhood
      Adolescent, Body Height, drug effects, Child, Cross-Sectional Studies, Drug Administration Schedule, Drug Monitoring, methods, Drug Prescriptions, statistics & numerical data, Female, Growth Disorders, drug therapy, physiopathology, Human Growth Hormone, administration & dosage, therapeutic use, Humans, Longitudinal Studies, Male, Patient Compliance, Recombinant Proteins, Treatment Outcome

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          Abstract

          Concordance with growth hormone (GH) therapy in 75 children was objectively assessed using data on GP prescriptions over 12 months. 23% missed >2 injections/week. Lower concordance was associated with longer duration on GH therapy (p<0.005), lack of choice of delivery device (p<0.005) and short prescription durations (p<0.005), and predicted lower height velocities (p<0.05).

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