Consumption of Diet Soda Sweetened with Sucralose and Acesulfame-Potassium Alters Inflammatory Transcriptome Pathways in Females with Overweight and Obesity.

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Abstract

Low-calorie sweetener (LCS) consumption is associated with metabolic disease in observational studies. However, physiologic mechanisms underlying LCS-induced metabolic impairments in humans are unclear. This study is aimed at identifying molecular pathways in adipose impacted by LCSs.

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Journal

Journal ID (iso-abbrev): Mol Nutr Food Res

Title: Molecular nutrition & food research

Publisher: Wiley

ISSN (Electronic): 1613-4133

ISSN (Print): 1613-4125

Publication date (Electronic): June 2020

Volume: 64

Issue: 11

Affiliations

[1 ] Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Avenue NW, Washington, DC, 20052, USA.

[2 ] Division of Endocrinology, George Washington University School of Medicine, 2120 L. St NW, Suite 450, Washington, DC, 20037, USA.

[3 ] Computational Biology Institute, Milken Institute School of Public Health, The George Washington University, 800 22nd Street, NW, 7000 Science and Engineering Hall, Washington, DC, 20052, USA.

[4 ] Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Dr., Room 433A, Atlanta, GA, 30322, USA.

[5 ] Intramural Research Program, NIDDK, NIH (PJW, KIR), 9000 Rockville Pike, Building 10, Room 8C432A, Bethesda, MD, 20892, USA.

[6 ] Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, The George Washington University, 950 New Hampshire Avenue NW, Washington, DC, 20052, USA.

[7 ] Department of Kinesiology, School of Health and Human Services, Indiana University Purdue University Indianapolis, PE 266, 901 W. New York Street, Indianapolis, IN, 46202, USA.

Article

DOI: 10.1002/mnfr.201901166

PubMed ID: 32281732

SO-VID: 3a9b4e13-416f-4287-91d5-9c70bf30c5a4

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Keywords: artificial sweeteners,sucralose,obesity,metabolism,diet soda,inflammation

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Keywords: artificial sweeteners, sucralose, obesity, metabolism, diet soda, inflammation

Consumption of Diet Soda Sweetened with Sucralose and Acesulfame-Potassium Alters Inflammatory Transcriptome Pathways in Females with Overweight and Obesity.

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