During summer months the proportion of acute enteric infections caused by non-cholera vibrios reaches was found to reach 11.4%. Their etiological factors were V. fluvialis (30.3%), V. parahaemolyticus (27.3%), V. costicola (21.2%) and V. damsela (21.2%). As revealed in this study, cases of infection in humans caused by vibrios, with the exception of V. costicola, were more closely linked with the contamination of water than that of fish (the correlation coefficients were equal, respectively, to 0.782 and 0.443). Suggestion was made that cases of human infections were caused not only by infective agents brought seafood, but also by vibrios inhabiting the Volga and contaminating fresh-water fish. The necessity of epidemiological surveillance on diseases caused by noncholera vibrios is substantiated.