Downregulation of ELAVL1 attenuates ferroptosis-induced neuronal impairment in rats with cerebral ischemia/reperfusion via reducing DNMT3B-dependent PINK1 methylation.

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Abstract

Ferroptosis is a non-apoptotic form of programmed cell death and has been found in ischemic stroke. Increasing evidence revealed that ELAVL1 is associated with ferroptosis, but it remains largely unclear whether ELAVL1 is involved in ischemic stroke. Here, we aimed to investigate the biological role and mechanism of ELAVL1 in cerebral ischemia/reperfusion (I/R) injury.

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Journal

Journal ID (iso-abbrev): Metab Brain Dis

Title: Metabolic brain disease

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1573-7365

ISSN (Print): 0885-7490

Publication date (Electronic): Dec 2022

Volume: 37

Issue: 8

Affiliations

[1 ] Department of Neurology, The Second Affiliated Hospital of Xi'an Jiaotong University, No.157, Xi Wu Road, Xin Cheng District, 710004, Xi'an, Shaanxi Province, China. du_yun1007@163.com.

[2 ] Department of Neurology, The Second Affiliated Hospital of Xi'an Jiaotong University, No.157, Xi Wu Road, Xin Cheng District, 710004, Xi'an, Shaanxi Province, China.

Article

Publisher Item ID: 10.1007/s11011-022-01080-8

DOI: 10.1007/s11011-022-01080-8

PubMed ID: 36173508

SO-VID: 3c642120-0bba-4ea6-8efa-febb1ad6811d

History

Keywords: DNMT3B,ELAVL1,Ferroptosis,PINK1,ischemia/reperfusion

Data availability:

Keywords: DNMT3B, ELAVL1, Ferroptosis, PINK1, ischemia/reperfusion

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