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High-dose naloxone affects task performance in normal subjects
February 1983
February 1983
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Abstract
Increasing intravenous doses of naloxone (0.3 mg/kg, 1 mg/kg, and 2 mg/kg) were administered
to normal subjects. Naloxone at 2 mg/kg, but not at lower doses, impaired aspects
of memory as measured by a verbal learning task which assessed the direct free recall
and recognition of presented versus non-presented words of a single category (effortful
processing) and the monitoring of the frequency of such presentations (automatic processing).
At the same time "working" memory was left unaffected. The results suggest a role
for the opioid system in some memory processes in man.