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      Fucoidan reduces oxidative stress by regulating the gene expression of HO‑1 and SOD‑1 through the Nrf2/ERK signaling pathway in HaCaT cells.

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      Molecular medicine reports

      Spandidos Publications

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          Abstract

          Fucoidan, a sulfated polysaccharide, is found in edible brown algae. In the present study, the molecular mechanisms of fucoidan against mild oxidative stress in human keratinocytes were investigated. The current study indicated that fucoidan significantly augmented the antioxidants heme oxygenase‑1 (HO‑1) and superoxide dismutase‑1 (SOD‑1) via the upregulation of nuclear factor erythroid 2‑related factor 2 (Nrf2) and markedly reduced the cytoplasmic stability of kelch‑like ECH‑associated protein 1. The upregulation of HO‑1 and SOD‑1 detected in the fucoidan‑treated cells may be responsible for the increased resistance to mild oxidative stress, indicating that fucoidan may augment the activities of antioxidant enzymes via stimulating Nrf2. This is the first report, to the best of our knowledge, to demonstrate that fucoidan attenuates oxidative stress by regulating the gene expression of SOD‑1 and HO‑1 via the Nrf2/extracellular signal‑regulated kinase signaling pathway.

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          Author and article information

          Journal
          Mol Med Rep
          Molecular medicine reports
          Spandidos Publications
          1791-3004
          1791-2997
          Oct 2016
          : 14
          : 4
          Affiliations
          [1 ] Department of Food and Nutrition, College of Natural Sciences, Duksung Women's University, Seoul 01369, Republic of Korea.
          Article
          10.3892/mmr.2016.5623
          27513069

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