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      Correction: CD73 Is Dispensable for the Regulation of Inflationary CD8 + T-Cells after Murine Cytomegalovirus Infection and Adenovirus Immunisation

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      Author(s): The PLOS ONE Staff
      Publication date (Electronic):
      Journal: PLoS ONE
      Publisher: Public Library of Science

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          Abstract

          Dr. Beatrice Bolinger is not included in the author byline. She should be listed as the third author, and her affiliation is 3: Department of Biomedicine, University of Basel, Hebelstrasse 20, 4056 Basel. The contributions of this author are as follows: Conceived and designed the experiments. The correct citation is: Sims S, Colston J, Bolinger B, Emery V, Klenerman P (2014) CD73 Is Dispensable for the Regulation of Inflationary CD8+ T-Cells after Murine Cytomegalovirus Infection and Adenovirus Immunisation. PLoS ONE 9(12): e114323. doi:10.1371/journal.pone.0114323

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          CD73 Is Dispensable for the Regulation of Inflationary CD8+ T-Cells after Murine Cytomegalovirus Infection and Adenovirus Immunisation

          Stuart Sims, Julia Colston, Vince Emery … (2014)
          The ecto-5'-nucleotidase (CD73) is expressed by T-cell subsets, myeloid derived suppressive cells and endothelial cells. It works in conjunction with CD39 to regulate the formation and degradation of adenosine in vivo. Adenosine has previously been shown to suppress the proliferation and cytokine secretion of T-cells and recent evidence suggests that inhibition of CD73 has the potential to enhance T-cell directed therapies. Here we utilised a CD73 knockout mouse model to assess the suppressive ability of CD73 on CD8+ T-cell classical memory and memory “inflation”, induced by murine cytomegalovirus (MCMV) infection and adenovirus immunisation. We show that CD73 is dispensable for normal CD8+ T-cell differentiation and function in both models. Thus CD73 as a suppressor of CD8+ T-cells is unlikely to play a deterministic role in the generation and functional characteristics of antiviral memory in these settings.
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            Journal
            Journal ID (nlm-ta): PLoS One
            Journal ID (iso-abbrev): PLoS ONE
            Journal ID (publisher-id): plos
            Journal ID (pmc): plosone
            Title: PLoS ONE
            Publisher: Public Library of Science (San Francisco, CA USA )
            ISSN (Electronic): 1932-6203
            Publication date (Electronic): 25 March 2015
            Publication date Collection: 2015
            Volume: 10
            Issue: 3
            Electronic Location Identifier: e0121925
            Article
            Publisher ID: PONE-D-15-07886
            DOI: 10.1371/journal.pone.0121925
            PMC ID: 4373878
            PubMed ID: 25807008
            SO-VID: 3cf7500d-31da-4550-a86f-f34062735671
            Copyright statement: Copyright @ 2015
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            This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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            CD73 Is Dispensable for the Regulation of Inflationary CD8+ T-Cells after Murine Cytomegalovirus Infection and Adenovirus Immunisation
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            Subject: Correction

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