Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis.

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Abstract

Pathological complete response has been proposed as a surrogate endpoint for prediction of long-term clinical benefit, such as disease-free survival, event-free survival (EFS), and overall survival (OS). We had four key objectives: to establish the association between pathological complete response and EFS and OS, to establish the definition of pathological complete response that correlates best with long-term outcome, to identify the breast cancer subtypes in which pathological complete response is best correlated with long-term outcome, and to assess whether an increase in frequency of pathological complete response between treatment groups predicts improved EFS and OS.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

Publisher: Elsevier BV

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Jul 12 2014

Volume: 384

Issue: 9938

Affiliations

[1 ] US Food and Drug Administration, Silver Spring, MD, USA. Electronic address: patricia.cortazar@fda.hhs.gov.

[2 ] US Food and Drug Administration, Silver Spring, MD, USA.

[3 ] HELIOS Klinikum, Berlin, Germany.

[4 ] German Breast Group, Neu-Isenburg, Germany.

[5 ] National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA.

[6 ] Institut Bergonié INSERM U916 and Université Bordeaux Segalen, Bordeaux, France.

[7 ] Edinburgh Cancer Research Centre, University of Edinburgh and NHS Lothian, UK.

[8 ] San Raffaele Scientific Institute, Milan, Italy.

[9 ] Fondazione Michelangelo, Milan, Italy.

[10 ] Medstar Washington Hospital Center, Washington, DC, USA.

[11 ] EORTC Headquarters, Brussels, Belgium.

[12 ] Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

[13 ] Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.

[14 ] St Gertrauden Hospital, Berlin, Germany.

[15 ] MD Anderson Cancer Center Orlando, Orlando, FL, USA.

[16 ] KarolinskaInstitutet and University Hospital, Stockholm, Sweden.

[17 ] NN Petrov Research Institute of Oncology, St Petersburg, Russia.

[18 ] University Women's Hospital, Kiel, Germany.

[19 ] Jules Bordet Institute, Brussels, Belgium.

[20 ] Frauenklinik des Universitätsklinikums, Erlangen, Germany.

[21 ] Universitäts Frauenklinik, Rostock, Germany.

[22 ] Virginia Commonwealth University Massey Cancer Center, Richmond, VA, USA.

[23 ] Hospital of the Ludwig Maximilian University of Munich, Munich, Germany.

Article

Publisher Item ID: S0140-6736(13)62422-8

DOI: 10.1016/S0140-6736(13)62422-8

PubMed ID: 24529560

SO-VID: 3d72a40e-1c79-4af4-91f7-6d776d3efa49

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