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Synthesis of Secondary Unsaturated Lactams via an Aza-Heck Reaction
October 14 2016
October 18 2016
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Abstract
<p class="first" id="P1">The preparation of unsaturated secondary lactams via the
palladium-catalyzed cyclization
of
<i>O</i>-phenyl hydroxamates onto a pendent alkene is reported. This method provides
rapid
access to a broad range of lactams that are widely useful building blocks in alkaloid
synthesis. Mechanistic studies support an aza-Heck-type pathway.
</p><p id="P2">
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<img alt="" class="figure" src="/document_file/6452bcaf-026f-434e-9d3e-5240a3a0b814/PubMedCentral/image/nihms-823972-f0001.jpg"/>
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</p>