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      Síndrome de Guillain-Barré concomitante con infección por virus Zika Translated title: Guillain-Barre syndrome associated with Zika virus infection.

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          Abstract

          Resumen OBJETIVOS Comunicar una serie de casos de síndrome de Guillain-Barré y describir las características clínicas de una posible asociación con infección previa por virus Zika. MATERIAL Y MÉTODO Estudio descriptivo de serie de casos en el que se recolectaron datos clínicos, bioquímicos y demográficos de los pacientes con síndrome de Guillain-Barré tratados en el Hospital General Acapulco con antecedente reciente de síndrome viral agudo sospechoso de infección por virus Zika, del 24 de julio al 24 de agosto de 2016, con realización de estudio de líquido cefalorraquídeo y comprobación de disociación albúmino-citológica. Se estableció diagnóstico de certeza de síndrome de Guillain-Barré según los criterios de Asbury-Cornblath y Brighton. RESULTADOS Se estudiaron 10 pacientes con síndrome de Guillain-Barré y antecedente reciente de síndrome viral agudo compatible con infección por virus Zika; la edad media de los sujetos en estudio fue de 47.8 años, 4 eran hombres. Los déficits motor y sensitivo sobrevinieron en una mediana de 4.5 y 4.3 días, respectivamente, después del inicio de los síntomas de infección viral. Hubo complicaciones, como neumonía asociada con ventilación mecánica, infección de vías urinarias en tres casos y disautonomía en dos casos. CONCLUSIONES Todos los casos de este brote de síndrome de Guillain-Barré tenían antecedente reciente de infección sospechosa por virus Zika, lo que refuerza la evidencia existente de la asociación entre el síndrome de Guillain-Barré y la infección por virus Zika.

          Translated abstract

          Abstract OBJECTIVES To communicate a series of cases of Guillain-Barre syndrome and to describe the clinical characteristics related to a possible association with previous infection due to Zika virus. MATERIAL AND METHOD A descriptive study of series of cases in which clinical, biochemical and demographic data were collected from patients with Guillain-Barre syndrome treated at the Hospital General Acapulco with a recent history of acute viral syndrome suspected of infection due to Zika virus, performed from July 24 to August 24, 2016, with conducting study of cerebrospinal fluid and ascertainment of cytological albuminous dissociation. A certainty diagnosis was established for Guillain-Barre syndrome according to the criteria of Asbury-Cornblath and Brighton. RESULTS Ten patients with GBS and a recent history of acute viral syndrome compa-tible with Zika virus infection were included. The mean age was 47.8 years, 4 were male. The motor and sensitive deficits were developed at a median of 4.5 and 4.3 days, respectively after the onset of symptoms of viral infection. The complications found were ventilator-associated pneumonia, urinary tract infection and dysautonomia. CONCLUSIONS All cases of this outbreak of Guillain-Barre syndrome had a recent history of suspected infection due to Zika virus, reinforcing the evidence for the association between Guillain-Barre syndrome and infection due to Zika virus.

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          Most cited references16

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          Zika virus infection complicated by Guillain-Barré syndrome – case report, French Polynesia, December 2013

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            Guillain-Barré syndrome associated with the Zika virus outbreak in Brazil

            ABSTRACT Zika virus (ZIKV) is now considered an emerging flavivirosis, with a first large outbreak registered in the Yap Islands in 2007. In 2013, a new outbreak was reported in the French Polynesia, with associated cases of neurological complications including Guillain-Barré syndrome (GBS). The incidence of GBS has increased in Brazil since 2015, what is speculated to be secondary to the ZIKV infection outbreak. The gold-standard test for detection of acute ZIKV infection is the polymerase-chain reaction technique, an essay largely unavailable in Brazil. The diagnosis of GBS is feasible even in resource-limited areas using the criteria proposed by the GBS Classification Group, which is based solely on clinical grounds. Further understanding on the relationship of ZIKV with neurological complications is a research urgency.
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              Time Lags between Exanthematous Illness Attributed to Zika Virus, Guillain-Barré Syndrome, and Microcephaly, Salvador, Brazil

              There is strong evidence of a temporal relationship between virus infection in pregnant women and birth outcome.
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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                mim
                Medicina interna de México
                Med. interna Méx.
                Edición y Farmacia S.A. de C.V. (Ciudad de México, Ciudad de México, Mexico )
                0186-4866
                October 2018
                : 34
                : 5
                : 667-677
                Affiliations
                [3] Acapulco de Juárez Guerrero orgnameHospital General de Acapulco México
                [4] Acapulco de Juárez Guerrero orgnameHospital General de Acapulco México
                [1] Acapulco de Juárez Guerrero orgnameHospital General de Acapulco México
                [6] Acapulco de Juárez Guerrero orgnameHospital General de Acapulco México
                [2] Acapulco de Juárez Guerrero orgnameHospital General de Acapulco México
                [5] Acapulco de Juárez Guerrero orgnameHospital General de Acapulco México
                Article
                S0186-48662018000500002
                10.24245/mim.v34i5.1778
                3ea4d17f-ff08-45e8-96ae-5572da34aebb

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 01 November 2017
                : 18 June 2018
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 22, Pages: 11
                Product

                SciELO Mexico

                Categories
                Artículos originales

                Virus Zika,síndrome de Guillain-Barré,Zika virus,Guillain-Barre syndrome

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