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      Effects of sleep deprivation on the limbic system and the frontal lobes in affective disorders: a study with Tc-99m-HMPAO SPECT.

      Psychiatry Research
      Adult, Blood Flow Velocity, physiology, Brain Mapping, Cerebral Cortex, blood supply, radionuclide imaging, Depressive Disorder, therapy, Dominance, Cerebral, Female, Frontal Lobe, Hippocampus, Humans, Limbic System, Male, Middle Aged, Organotechnetium Compounds, diagnostic use, Oximes, Regional Blood Flow, Sleep Deprivation, Technetium Tc 99m Exametazime, Tomography, Emission-Computed, Single-Photon, methods

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          Abstract

          We studied 10 patients with melancholia before and after sleep deprivation and 8 controls with Tc-99m-hexamethylpropylenamineoxime (HMPAO) single photon emission computed tomography (SPECT). All depressed subjects showed relative hypoperfusion in the left anterolateral prefrontal cortex under both conditions. Only responders showed relative hyperperfusion in parts of the limbic system and a reduction of blood flow in these regions after sleep deprivation.

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