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      Hypertension as a risk factor for atherosclerosis: Cardiovascular risk assessment

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          Abstract

          Atherosclerosis is a predecessor of numerous cardiovascular diseases (CVD), which often lead to morbidity and mortality. Despite the knowledge of the pathogenesis of atherosclerosis, an essential gap in our understanding is the exact trigger mechanism. A wide range of risk factors have been discovered; however, a majority of them are too general to clarify the launching mechanism of atherogenesis. Some risk factors are permanent (age, gender, genetic heritage) and others can be modified [tobacco smoking, physical inactivity, poor nutrition, high blood pressure, type 2 diabetes (T2D), dyslipidemia, and obesity]. All of them have to be taken into account. In the scope of this review, our attention is focused on hypertension, which is considered the most widespread among all modifiable risk factors for atherosclerosis development. Moreover, high blood pressure is the most investigated risk factor. The purpose of this review is to summarize the data on hypertension as a risk factor for atherosclerosis development and the risk assessment.

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          Most cited references67

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          Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association

          The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). The American Heart Association, through its Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update. The 2021 Statistical Update is the product of a full year’s worth of effort by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. This year’s edition includes data on the monitoring and benefits of cardiovascular health in the population, an enhanced focus on social determinants of health, adverse pregnancy outcomes, vascular contributions to brain health, the global burden of cardiovascular disease, and further evidence-based approaches to changing behaviors related to cardiovascular disease. Each of the 27 chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. The Statistical Update represents a critical resource for the lay public, policy makers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.
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            2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts)Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR).

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                Author and article information

                Contributors
                Journal
                Front Cardiovasc Med
                Front Cardiovasc Med
                Front. Cardiovasc. Med.
                Frontiers in Cardiovascular Medicine
                Frontiers Media S.A.
                2297-055X
                22 August 2022
                2022
                : 9
                : 959285
                Affiliations
                [1] 1Institute for Atherosclerosis Research , Moscow, Russia
                [2] 2Petrovsky National Research Centre of Surgery , Moscow, Russia
                [3] 3Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology , Moscow, Russia
                [4] 4Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology , Moscow, Russia
                Author notes

                Edited by: Mirza S. Baig, Indian Institute of Technology Indore, India

                Reviewed by: Alexander M. Markin, Russian National Research Center of Surgery Named After B.V. Petrovsky, Russia; Antonina Starodubova, Federal Research Center of Nutrition, Biotechnology and Food Safety, Russia; Veronika Myasoedova, Monzino Cardiology Center (IRCCS), Italy

                *Correspondence: Anastasia V. Poznyak, tehhy_85@ 123456mail.ru

                This article was submitted to Atherosclerosis and Vascular Medicine, a section of the journal Frontiers in Cardiovascular Medicine

                Article
                10.3389/fcvm.2022.959285
                9441708
                36072873
                3fd69cf8-1703-43d5-8b63-8846f047dab7
                Copyright © 2022 Poznyak, Sadykhov, Kartuesov, Borisov, Melnichenko, Grechko and Orekhov.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 01 June 2022
                : 18 July 2022
                Page count
                Figures: 1, Tables: 1, Equations: 0, References: 67, Pages: 8, Words: 6357
                Funding
                Funded by: Russian Science Foundation, doi 10.13039/501100006769;
                Award ID: 20-65-46021
                Categories
                Cardiovascular Medicine
                Review

                atherosclerosis,hypertension,cardiovascular disease,cardiovascular risk,vessels

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