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Influence of gastrectomy on the distribution of intravenously administered 5-fluorouracil to regional lymph nodes in an animal model.
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Abstract
Neoadjuvant and postoperative chemotherapies have been widely employed for the treatment of patients with gastric carcinoma. However, to the authors' knowledge there have been no studies that focused on pharmacokinetic differences between antineoplastic agents administered before versus after gastrectomy. The influence of gastrectomy on the distribution of antineoplastic agents, especially to the regional lymph nodes, were examined.