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      Revisiting concepts of evidence in implementation science

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          Abstract

          Background

          Evidence, in multiple forms, is a foundation of implementation science. For public health and clinical practice, evidence includes the following: type 1 evidence on etiology and burden; type 2 evidence on effectiveness of interventions; and type 3: evidence on dissemination and implementation (D&I) within context. To support a vision for development and use of evidence in D&I science that is more comprehensive and equitable (particularly for type 3 evidence), this article aims to clarify concepts of evidence, summarize ongoing debates about evidence, and provide a set of recommendations and tools/resources for addressing the “how-to” in filling evidence gaps most critical to advancing implementation science.

          Main text

          Because current conceptualizations of evidence have been relatively narrow and insufficiently characterized in our opinion, we identify and discuss challenges and debates about the uses, usefulness, and gaps in evidence for implementation science. A set of questions is proposed to assist in determining when evidence is sufficient for dissemination and implementation. Intersecting gaps include the need to (1) reconsider how the evidence base is determined, (2) improve understanding of contextual effects on implementation, (3) sharpen the focus on health equity in how we approach and build the evidence-base, (4) conduct more policy implementation research and evaluation, and (5) learn from audience and stakeholder perspectives. We offer 15 recommendations to assist in filling these gaps and describe a set of tools for enhancing the evidence most needed in implementation science.

          Conclusions

          To address our recommendations, we see capacity as a necessary ingredient to shift the field’s approach to evidence. Capacity includes the “push” for implementation science where researchers are trained to develop and evaluate evidence which should be useful and feasible for implementers and reflect community or stakeholder priorities. Equally important, there has been inadequate training and too little emphasis on the “pull” for implementation science (e.g., training implementers, practice-based research). We suggest that funders and reviewers of research should adopt and support a more robust definition of evidence. By critically examining the evolving nature of evidence, implementation science can better fulfill its vision of facilitating widespread and equitable adoption, delivery, and sustainment of scientific advances.

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          Most cited references180

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          A new framework for developing and evaluating complex interventions: update of Medical Research Council guidance

          The UK Medical Research Council’s widely used guidance for developing and evaluating complex interventions has been replaced by a new framework, commissioned jointly by the Medical Research Council and the National Institute for Health Research, which takes account of recent developments in theory and methods and the need to maximise the efficiency, use, and impact of research.
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            Racism and Health: Evidence and Needed Research

            In recent decades, there has been remarkable growth in scientific research examining the multiple ways in which racism can adversely affect health. This interest has been driven in part by the striking persistence of racial/ethnic inequities in health and the empirical evidence that indicates that socioeconomic factors alone do not account for racial/ethnic inequities in health. Racism is considered a fundamental cause of adverse health outcomes for racial/ethnic minorities and racial/ethnic inequities in health. This article provides an overview of the evidence linking the primary domains of racism—structural racism, cultural racism, and individual-level discrimination—to mental and physical health outcomes. For each mechanism, we describe key findings and identify priorities for future research. We also discuss evidence for interventions to reduce racism and describe research needed to advance knowledge in this area.
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              The social determinants of health: coming of age.

              In the United States, awareness is increasing that medical care alone cannot adequately improve health overall or reduce health disparities without also addressing where and how people live. A critical mass of relevant knowledge has accumulated, documenting associations, exploring pathways and biological mechanisms, and providing a previously unavailable scientific foundation for appreciating the role of social factors in health. We review current knowledge about health effects of social (including economic) factors, knowledge gaps, and research priorities, focusing on upstream social determinants-including economic resources, education, and racial discrimination-that fundamentally shape the downstream determinants, such as behaviors, targeted by most interventions. Research priorities include measuring social factors better, monitoring social factors and health relative to policies, examining health effects of social factors across lifetimes and generations, incrementally elucidating pathways through knowledge linkage, testing multidimensional interventions, and addressing political will as a key barrier to translating knowledge into action.
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                Author and article information

                Contributors
                rbrownson@wustl.edu
                rs3108@cumc.columbia.edu
                elvin.geng@wustl.edu
                russell.glasgow@cuanschutz.edu
                Journal
                Implement Sci
                Implement Sci
                Implementation Science : IS
                BioMed Central (London )
                1748-5908
                12 April 2022
                12 April 2022
                2022
                : 17
                : 26
                Affiliations
                [1 ]GRID grid.4367.6, ISNI 0000 0001 2355 7002, Prevention Research Center, , Brown School at Washington University in St. Louis, ; One Brookings Drive, Campus, Box 1196, St. Louis, MO 63130 USA
                [2 ]GRID grid.4367.6, ISNI 0000 0001 2355 7002, Department of Surgery, Division of Public Health Sciences, and Alvin J. Siteman Cancer Center, , Washington University School of Medicine, Washington University in St. Louis, ; St. Louis, MO 63130 USA
                [3 ]GRID grid.21729.3f, ISNI 0000000419368729, Department of Sociomedical Sciences, , Columbia University Mailman School of Public Health, ; New York, NY 10032 USA
                [4 ]GRID grid.4367.6, ISNI 0000 0001 2355 7002, Division of Infectious Diseases, Department of Medicine and Center for Dissemination and Implementation in the Institute for Public Health, , Washington University School of Medicine, Washington University in St. Louis, ; St. Louis, MO 63110 USA
                [5 ]GRID grid.430503.1, ISNI 0000 0001 0703 675X, Department of Family Medicine and Adult & Child Consortium for Health Outcomes Research and Delivery Science, , University of Colorado School of Medicine, University of Colorado Anschutz Medical Campus, ; Aurora, CO 80045 USA
                Author information
                http://orcid.org/0000-0003-4260-2205
                Article
                1201
                10.1186/s13012-022-01201-y
                9004065
                35413917
                41396841-1aa8-4492-bf7e-96aff3f9cbb9
                © The Author(s) 2022

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                : 30 October 2021
                : 4 April 2022
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/100000002, National Institutes of Health;
                Award ID: P50CA244431
                Award ID: P50CA244688
                Award ID: P50CA244690
                Award ID: R01CA255382
                Award ID: P30DK092950
                Award ID: R25DK123008
                Award ID: P30DK056341
                Award Recipient :
                Funded by: FundRef http://dx.doi.org/10.13039/100000030, Centers for Disease Control and Prevention;
                Award ID: U48DP006395
                Funded by: FundRef http://dx.doi.org/10.13039/100000048, American Cancer Society;
                Award ID: RSG-17-156-01-CPPB
                Award Recipient :
                Categories
                Debate
                Custom metadata
                © The Author(s) 2022

                Medicine
                context,equity,evidence,implementation science
                Medicine
                context, equity, evidence, implementation science

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