The association between chronic sinusitis and hair ultra-trace element levels in hair of children

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Abstract

Abstract. The objective of the present study was to assess the association between hair levels of ultra-trace elements and chronic sinusitis in children. Hair samples of 66 children with chronic sinusitis (J32.0 – ICD-10) (mean age – 11.2 ± 4.5 years) and 66 gender-matched controls (mean age – 11.3 ± 4.6 years) were analyzed for Ag, Au, Ba, Bi, Ga, Ge, La, Mo, Pt, Rb, Sb, Tl, W, and Zr content using inductively-coupled plasma mass spectrometry at NexION 300D (PerkinElmer Inc., Shelton, CT, USA) after microwave digestion of hair samples. The obtained data demonstrate that hair Ga, Tl, and Zr were significantly increased by 20% (p = 0.004), 33% (p = 0.006), and 36% (p = 0.047), respectively, as compared to the control values. In turn, hair Pt levels were 2-fold higher in the group of patients when compared to the healthy controls (p = 0.003). A nearly significant (p = 0.066) 50% increase in hair Sb was observed. Correlation analysis demonstrated that in a group of healthy children, hair Au (–0.2657; p = 0.031), Sb (–0,3871; p = 0.001), W (–0,3046; p = 0.013), and Zr (–0.2766; p = 0.025) levels were significantly inversely correlated with age of the examinees, whereas no such associations were revealed in the patient group. We hypothesize that altered ciliary apparatus in chronic sinusitis patients may result in reduced removal of inhaled metal particles and their subsequent toxicity. 

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Characterization of silver nanoparticles synthesized by using marine isolate Streptomyces albidoflavus.

Girija Shankar Guntuku, Sudheer Kumar Yannam, Reddy Shetty Prakasham … (2012)

Silver nanoparticles production by the green chemistry approach was investigated using an isolated marine actinomycetes strain. The isolated strain was identified as Streptomyces albidoflavus based on chemotaxonomic and ribotyping properties. The strain revealed production of silver nanoparticles both extracellular and intracellularly. Surface Plasmon Resonance analysis with the function of time revealed that particle synthesis by this strain is reaction time dependent. The produced particles were spherical shaped and monodispersive in nature and showed a single surface plasmon resonance peak at 410 nm. Size distribution histograms indicated production of 10-40- nm-size nanoparticles with a mean size of 14.5 nm. FT-IR spectra of nanopartilces showed N-H, C-H, and C-N stretching vibrations, denoting the presence of amino acid/ peptide compounds on the surface of silver nanoparticles produced by S. albidoflavus. Synthesized nanoparticles revealed a mean negative zeta potential and electrophoretic mobility of -8.5 mV and -0.000066 cm2/Vs, respectively. The nanoparticles produced were proteinaceous compounds as capping agents with -8.5 mV zeta potential and revealed antimicrobial activity against both Gram-negative and -positive bacterial strains. Owing to their small size, these particles have greater impact on industrial application spectra.