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      NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?

      1 ,
      Nature reviews. Immunology
      Springer Science and Business Media LLC

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          Abstract

          The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein complex that activates caspase 1, leading to the processing and secretion of the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and IL-18. The NLRP3 inflammasome is activated by a wide range of danger signals that derive not only from microorganisms but also from metabolic dysregulation. It is unclear how these highly varied stress signals can be detected by a single inflammasome. In this Opinion article, we review the different signalling pathways that have been proposed to engage the NLRP3 inflammasome and suggest a model in which one of the crucial elements for NLRP3 activation is the generation of reactive oxygen species (ROS).

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          Author and article information

          Journal
          Nat Rev Immunol
          Nature reviews. Immunology
          Springer Science and Business Media LLC
          1474-1741
          1474-1733
          March 2010
          : 10
          : 3
          Affiliations
          [1 ] Department of Biochemistry, University of Lausanne, Epalinges, Switzerland. jurg.tschopp@unil.ch
          Article
          nri2725
          10.1038/nri2725
          20168318
          41d19239-0ba7-4747-b76d-afc510e23ca1
          History

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