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      Assessment of Hypertension Control Among Adults Participating in a Mobile Technology Blood Pressure Self-management Program

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      , PhD 1 , , BSc 1 , , MD, MAS 2 ,
      JAMA Network Open
      American Medical Association

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          Key Points

          Question

          Is engagement with a mobile technology blood pressure self-management program associated with long-term blood pressure control?

          Findings

          In this cohort study of 28 189 US adults with elevated blood pressure or hypertension participating in a hypertension self-management program with a blood pressure monitor and connected smartphone application with clinically based digital coaching, most participants achieved and maintained lower blood pressure during a follow-up period that lasted as long as 3 years.

          Meaning

          These findings suggest that mobile technology hypertension self-management programs may be useful for real-world blood pressure monitoring and control.

          Abstract

          This cohort study examines whether engagement with a hypertension self-management program with a blood pressure monitor and connected smartphone application was associated with blood pressure control among US adults.

          Abstract

          Importance

          It is unclear whether mobile technology hypertension self-management programs are associated with blood pressure (BP) control.

          Objective

          To examine whether engagement with a hypertension self-management program with a BP monitor and connected smartphone application with clinically based digital coaching was associated with BP control during a follow-up period of as long as 3 years.

          Design, Setting, and Participants

          This cohort study enrolled US adults with elevated BP or hypertension between January 1, 2015, and July 1, 2020. The hypertension self-management program was provided through the participant’s (or their spouse’s) employer health plan.

          Exposures

          Program engagement, defined by average number of application sessions.

          Main Outcomes and Measures

          Systolic and diastolic BP measured by a US Food and Drug Administration–cleared BP monitor, with categories defined as normal (systolic BP, <120 mm Hg), elevated (systolic BP, 120-129 mm Hg), stage 1 hypertension (systolic BP, 130-139 mm Hg), and stage 2 hypertension (systolic BP ≥140 mm Hg). Other measures included age, gender, depression, anxiety, diabetes, high cholesterol, smoking, geographic region, area deprivation index, self-reported weight, and device-measured physical activity (steps per day).

          Results

          Among 28 189 participants (median [IQR] age, 51 [43-58] years; 9424 women [40.4%]; 13 902 men [59.6%]), median (IQR) baseline systolic BP was 129.5 mm Hg (120.5-139.6 mm Hg) and diastolic BP was 81.7 mm Hg (75.7-88.4 mm Hg). Median systolic BP at 1 year improved at least 1 category for 495 of 934 participants (53.0%) with baseline elevated BP, 673 of 966 (69.7%) with baseline stage 1 hypertension, and 920 of 1075 (85.7%) with baseline stage 2 hypertension. Participants in the program for 3 years had a mean (SEM) systolic BP reduction of 7.2 (0.4), 12.2 (0.7), and 20.9 (1.7) mm Hg compared with baseline for those starting with elevated, stage 1 hypertension, and stage 2 hypertension, respectively. Greater engagement was associated with lower systolic BP over time (high-engagement group: 131.2 mm Hg; 95% CI, 115.5-155.8 mm Hg; medium-engagement group: 133.4 mm Hg; 95% CI 116.3-159.5 mm Hg; low-engagement group: 135.5 mm Hg; 95% CI, 117.3-164.8 mm Hg; P < .001); these results persisted after adjusting for age, gender, depression, anxiety, diabetes, high cholesterol, smoking, area deprivation index rank, and US region, which was partially mediated by greater physical activity. A very high BP (systolic BP >180 mm Hg) was observed 11 637 times from 3778 participants. Greater engagement was associated with lower risk of very high BP; the estimated probability of a very high BP was greater in the low-engagement group (1.42%; 95% CI, 1.26%-1.59%) compared with the medium-engagement group (0.79%; 95% CI, 0.71%-0.87%; P < .001) and the high-engagement group (0.53%; 95% CI, 0.45%-0.60%; P < .001 for comparison with both groups).

          Conclusions and Relevance

          The findings of this study suggest that a mobile technology hypertension self-management program can support long-term BP control and very high BP detection. Such programs may improve real-world BP monitoring and control.

          Related collections

          Most cited references19

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          The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.

          Much biomedical research is observational. The reporting of such research is often inadequate, which hampers the assessment of its strengths and weaknesses and of a study's generalizability. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Initiative developed recommendations on what should be included in an accurate and complete report of an observational study. We defined the scope of the recommendations to cover 3 main study designs: cohort, case-control, and cross-sectional studies. We convened a 2-day workshop in September 2004, with methodologists, researchers, and journal editors, to draft a checklist of items. This list was subsequently revised during several meetings of the coordinating group and in e-mail discussions with the larger group of STROBE contributors, taking into account empirical evidence and methodological considerations. The workshop and the subsequent iterative process of consultation and revision resulted in a checklist of 22 items (the STROBE Statement) that relate to the title, abstract, introduction, methods, results, and discussion sections of articles. Eighteen items are common to all 3 study designs and 4 are specific for cohort, case-control, or cross-sectional studies. A detailed Explanation and Elaboration document is published separately and is freely available at http://www.annals.org and on the Web sites of PLoS Medicine and Epidemiology. We hope that the STROBE Statement will contribute to improving the quality of reporting of observational studies.
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            Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association

            The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). The American Heart Association, through its Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update. The 2021 Statistical Update is the product of a full year’s worth of effort by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. This year’s edition includes data on the monitoring and benefits of cardiovascular health in the population, an enhanced focus on social determinants of health, adverse pregnancy outcomes, vascular contributions to brain health, the global burden of cardiovascular disease, and further evidence-based approaches to changing behaviors related to cardiovascular disease. Each of the 27 chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. The Statistical Update represents a critical resource for the lay public, policy makers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.
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                Author and article information

                Journal
                JAMA Netw Open
                JAMA Netw Open
                JAMA Network Open
                American Medical Association
                2574-3805
                15 October 2021
                October 2021
                15 October 2021
                : 4
                : 10
                : e2127008
                Affiliations
                [1 ]Hello Heart, Tel Aviv, Israel
                [2 ]Department of Epidemiology & Biostatistics and Division of Cardiology, University of California, San Francisco
                Author notes
                Article Information
                Accepted for Publication: July 16, 2021.
                Published: October 15, 2021. doi:10.1001/jamanetworkopen.2021.27008
                Open Access: This is an open access article distributed under the terms of the CC-BY-NC-ND License. © 2021 Gazit T et al. JAMA Network Open.
                Corresponding Author: Alexis L. Beatty, MD, MAS, Department of Epidemiology & Biostatistics, University of California, San Francisco, Mission Hall, Global Health and Clinical Sciences, Box 0560, 550 16th St, San Francisco, CA 94143 ( alexis.beatty@ 123456ucsf.edu ).
                Author Contributions: Dr Gazit had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
                Concept and design: All authors.
                Acquisition, analysis, or interpretation of data: Gazit, Beatty.
                Drafting of the manuscript: All authors.
                Critical revision of the manuscript for important intellectual content: Gazit, Beatty.
                Statistical analysis: Gazit, Beatty.
                Supervision: Gazit, Gutman.
                Conflict of Interest Disclosures: Dr Gazit and Mrs Gutman reported being employed by Hello Heart and holding stock options. Dr Beatty reported having been employed by Apple from 2018 to 2019 and holding stock from 2018 to 2021.
                Funding/Support: Hello Heart funded the analysis. No funding was supplied to Dr Beatty.
                Role of the Funder/Sponsor: Hello Heart participated in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
                Article
                zoi210787
                10.1001/jamanetworkopen.2021.27008
                8520130
                34652447
                41e18778-4f8a-4d83-978b-a4acfafef183
                Copyright 2021 Gazit T et al. JAMA Network Open.

                This is an open access article distributed under the terms of the CC-BY-NC-ND License.

                History
                : 5 April 2021
                : 16 July 2021
                Categories
                Research
                Original Investigation
                Online Only
                Cardiology

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