Association between arginine vasopressin receptor 1A ( <i>AVPR1A</i>) polymorphism and inequity aversion

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Abstract

Although numerous studies have focused on brain functions related to inequity aversion, few have examined its genetic basis. Here, we show the association between estimated inequity aversion and polymorphisms in three genes associated with human sociality. Non-student adult participants took part in five economic game experiments on different days. Disadvantageous inequity aversion (DIA) and advantageous inequity aversion (AIA) were calculated from behavioural responses using Bayesian estimation. We investigated the association between genetic polymorphisms in the oxytocin receptor ( OXTR rs53576), arginine vasopressin receptor 1A ( AVPR1A RS3) and opioid receptor mu 1 ( OPRM1 rs1799971) and inequity aversion. Regarding AVPR1A RS3, participants with the SS genotype had higher AIA than those with the SL or LL genotypes, but no association was found for DIA. Moreover, we observed no aversion associations for OXTR rs53576 or OPRM1 rs1799971. The results suggest that AVPR1A plays an important role in aversion when one's own gain is greater than that of others. Our findings may provide a solid theoretical basis for future studies on the relationship between genetic polymorphisms and inequity aversion.

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Most cited references 72

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A Theory of Fairness, Competition, and Cooperation

E. Fehr, K. Schmidt (1999)

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In Search of Homo Economicus: Behavioral Experiments in 15 Small-Scale Societies

Joseph Henrich, Robert Boyd, Samuel Bowles … (2001)

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Altruistic punishment in humans.

Ernst Fehr, Simon Gächter (2002)

Human cooperation is an evolutionary puzzle. Unlike other creatures, people frequently cooperate with genetically unrelated strangers, often in large groups, with people they will never meet again, and when reputation gains are small or absent. These patterns of cooperation cannot be explained by the nepotistic motives associated with the evolutionary theory of kin selection and the selfish motives associated with signalling theory or the theory of reciprocal altruism. Here we show experimentally that the altruistic punishment of defectors is a key motive for the explanation of cooperation. Altruistic punishment means that individuals punish, although the punishment is costly for them and yields no material gain. We show that cooperation flourishes if altruistic punishment is possible, and breaks down if it is ruled out. The evidence indicates that negative emotions towards defectors are the proximate mechanism behind altruistic punishment. These results suggest that future study of the evolution of human cooperation should include a strong focus on explaining altruistic punishment.

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Author and article information

Contributors

Hiroki Tanaka:

ORCID: http://orcid.org/0000-0002-1699-5503

Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole: MethodologyRole: VisualizationRole: Writing – original draft

Kuniyuki Nishina:

ORCID: http://orcid.org/0000-0002-1250-0147

Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole: Writing – original draft

Qiulu Shou:

ORCID: http://orcid.org/0000-0002-7371-2557

Role: InvestigationRole: Writing – original draft

Hidehiko Takahashi:

ORCID: http://orcid.org/0000-0002-5102-1982

Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: Writing – review & editing

Masamichi Sakagami:

ORCID: http://orcid.org/0000-0003-1989-2793

Role: ConceptualizationRole: SupervisionRole: Writing – review & editing

Tetsuya Matsuda:

ORCID: http://orcid.org/0000-0002-1831-8311

Role: ConceptualizationRole: SupervisionRole: Writing – review & editing

Miho Inoue-Murayama:

ORCID: http://orcid.org/0000-0003-4249-876X

Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: MethodologyRole: ResourcesRole: SupervisionRole: Writing – review & editing

Haruto Takagishi:

ORCID: http://orcid.org/0000-0002-5143-9289

Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole: Project administrationRole: Writing – original draft

Journal

Journal ID (nlm-ta): Proc Biol Sci

Journal ID (iso-abbrev): Proc Biol Sci

Journal ID (publisher-id): RSPB

Journal ID (hwp): royprsb

Title: Proceedings of the Royal Society B: Biological Sciences

Publisher: The Royal Society

ISSN (Print): 0962-8452

ISSN (Electronic): 1471-2954

Publication date (Print, pub): June 14, 2023

Publication date (Electronic, pub): June 14, 2023

Publication date PMC-release: June 14, 2023

Volume: 290

Issue: 2000

Electronic Location Identifier: 20230378

Affiliations

[ ¹ ] Brain Science Institute, Tamagawa University, , Tokyo, 194-8610, Japan

[ ² ] Graduate School of Brain Sciences, Tamagawa University, , Tokyo, 194-8610, Japan

[ ³ ] Graduate School of Human Sciences, Osaka University, , Osaka, 565-0871, Japan

[ ⁴ ] Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, , Tokyo, 113-8519, Japan

[ ⁵ ] Wildlife Research Center, Kyoto University, , Kyoto, 606-8203, Japan

Author notes

[ † ]

These authors contributed equally.

Electronic supplementary material is available online at https://doi.org/10.6084/m9.figshare.c.6672285.

Author information

Hiroki Tanaka http://orcid.org/0000-0002-1699-5503

Kuniyuki Nishina http://orcid.org/0000-0002-1250-0147

Qiulu Shou http://orcid.org/0000-0002-7371-2557

Hidehiko Takahashi http://orcid.org/0000-0002-5102-1982

Masamichi Sakagami http://orcid.org/0000-0003-1989-2793

Tetsuya Matsuda http://orcid.org/0000-0002-1831-8311

Miho Inoue-Murayama http://orcid.org/0000-0003-4249-876X

Haruto Takagishi http://orcid.org/0000-0002-5143-9289

Article

Publisher ID: rspb20230378

DOI: 10.1098/rspb.2023.0378

PMC ID: 10265011

PubMed ID: 37312550

SO-VID: 42039db4-17cd-4846-b5eb-35640b956ca4

License:

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

History

Date received : July 1, 2022

Date accepted : May 19, 2023

Funding

Funded by: Takeda Science Foundation, http://dx.doi.org/10.13039/100007449;

Funded by: Cooperative Research Program of Wildlife Research Center;

Funded by: Japan Society for the Promotion of Science, http://dx.doi.org/10.13039/501100001691;

Award ID: JP19H04904

Award ID: JP19H04915

Award ID: JP19K14366

Award ID: JP20J01395

Award ID: JP25290082

Funded by: Japan Agency for Medical Research and Development, http://dx.doi.org/10.13039/100009619;

Award ID: JP18dm0307001

Award ID: JP18dm0307006

Award ID: JP21dm0307105

Custom metadata

cover-date June 14, 2023

ScienceOpen disciplines: Life sciences

Keywords: inequity aversion,economic game,genetic polymorphism,oxytocin receptor,arginine vasopressin receptor 1a,opioid receptor mu 1

Data availability:

ScienceOpen disciplines: Life sciences

Keywords: inequity aversion, economic game, genetic polymorphism, oxytocin receptor, arginine vasopressin receptor 1a, opioid receptor mu 1

Association between arginine vasopressin receptor 1A ( AVPR1A) polymorphism and inequity aversion

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Most cited references 72

A Theory of Fairness, Competition, and Cooperation

In Search of Homo Economicus: Behavioral Experiments in 15 Small-Scale Societies

Altruistic punishment in humans.

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