Ruxolitinib ameliorated coxsackievirus B3-induced acute viral myocarditis by suppressing the JAK-STAT pathway.

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Abstract

Accumulating evidences have demonstrated that overwhelming inflammation occurs in the process of Coxsackievirus B3 (CVB3)-induced acute viral myocarditis (AVM). No specific therapy is available. More than an effective Janus-associated kinase (JAK) inhibiter, ruxolitinib exerts a critical role in the inflammatory diseases. In this study, we investigated the potential effect of ruxolitinib on CVB3-induced acute viral myocarditis.

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Author and article information

Journal

Journal ID (iso-abbrev): Int Immunopharmacol

Title: International immunopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1878-1705

ISSN (Print): 1567-5769

Publication date (Electronic): Nov 2023

Volume: 124

Issue: Pt A

Affiliations

[1 ] Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

[2 ] Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

[3 ] Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, Hubei 430030, China.

[4 ] Institute of Pharmaceutical Innovation, College of Medicine, Wuhan University of Science and Technology, Wuhan 430065, Hubei, China.

[5 ] Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: linli@tjh.tjmu.edu.cn.

[6 ] Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: lltongji2015@163.com.

[7 ] Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: wuting@tjh.tjmu.edu.

Article

Publisher Item ID: S1567-5769(23)01122-0

DOI: 10.1016/j.intimp.2023.110797

PubMed ID: 37634445

SO-VID: 426b0af2-dfe6-4332-995d-f0709128fd65

History

Keywords: Coxsackievirus B3,Ruxolitinib,Janus-associated kinase,Inflammation,Acute viral myocarditis

Data availability:

Keywords: Coxsackievirus B3, Ruxolitinib, Janus-associated kinase, Inflammation, Acute viral myocarditis

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