Contributors
Yang Wang: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: SoftwareRole:
Writing – original draft
Chen Chen: Role: Data curationRole: Formal analysisRole: SoftwareRole: Writing – original draft
Yu Yan: Role: Data curationRole: Formal analysisRole: Investigation
Yue Yuan: Role: Investigation
Ke-Ke Wang: Role: Investigation
Chao Chu: Role: Investigation
Jia-Wen Hu: Role: Investigation
Qiong Ma: Role: Investigation
Yue-Yuan Liao: Role: Investigation
Bo-Wen Fu: Role: Methodology
Ke Gao: Role: Methodology
Yue Sun: Role: Supervision
Yong-Bo Lv: Role: Investigation
Wen-Jing Zhu: Role: Supervision
Lei Yang: Role: Supervision
Jie Zhang: Role: Investigation
Rui-Hai Yang: Role: Resources
Jun Yang: Role: Resources
Jian-Jun Mu:
ORCID: http://orcid.org/0000-0002-0335-3528
Role: ConceptualizationRole: Writing – review & editing
Gianpaolo Reboldi: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
15
November
2019
Publication date Collection: 2019
Volume: 14
Issue: 11
Electronic Location Identifier: e0224680
Affiliations
[1
]
Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong
University, Xi’an, China
[2
]
Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi’an, China
[3
]
Department of Cardiology, Second Affiliated Hospital of Xi’an Jiaotong University,
Xi’an, China
[4
]
Department of Cardiology, Xi’an Fourth People’s Hospital, Xi’an, China
[5
]
Institute of Cardiovascular Sciences, Hanzhong People’s Hospital, Hanzhong, China
Universita degli Studi di Perugia, ITALY
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-19-09294
DOI: 10.1371/journal.pone.0224680
PMC ID: 6857911
PubMed ID: 31730636
SO-VID: 44604a96-623d-4ed0-b9eb-4fff38496489
Copyright © © 2019 Wang et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 22
April
2019
Date
accepted
: 18
October
2019
Page count
Figures: 1,
Tables: 7,
Pages: 15
Funding
Funded by: funder-id http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;
Award ID: 81600327
Award Recipient
:
Yang Wang
Funded by: funder-id http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;
Award ID: 81570381, 81870319
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0335-3528
Jian-Jun Mu
Funded by: funder-id http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;
Award ID: 81700368
Award Recipient
:
Chao Chu
Funded by: funder-id http://dx.doi.org/10.13039/501100010031, Postdoctoral Research Foundation of China;
Award ID: 2018T111075
Award Recipient
:
Yang Wang
Funded by: funder-id http://dx.doi.org/10.13039/501100010031, Postdoctoral Research Foundation of China;
Award ID: 2018M631177
Award Recipient
:
Yang Wang
Funded by: funder-id http://dx.doi.org/10.13039/501100012226, Fundamental Research Funds for the Central Universities;
Award ID: xjj2018103
Award Recipient
:
Yang Wang
Funded by: the Clinical Research Award of the First Affiliated Hospital of Xi’an Jiaotong University
Award ID: XJTU1AF-CRF-2017-021
Award Recipient
:
Yang Wang
Funded by: funder-id http://dx.doi.org/10.13039/501100013076, National Major Science and Technology Projects of China;
Award ID: 2016YFC1300104 and 2017YFC1307604
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0335-3528
Jian-Jun Mu
Funded by: Key Research Project of Shaanxi Province
Award ID: 2017ZDXM-SF-107
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0335-3528
Jian-Jun Mu
This work was supported by the National Natural Science Foundation of China No. 81600327
(Y.W.), No. 81870319, 81570381 (J.-J.M.) and No. 81700368 (C.C.), the Grants from
China Postdoctoral Science Foundation No. 2018T111075 and 2018M631177 (Y.W.), Fundamental
Research Funds for the Central Universities No. xjj2018103 (Y.W.), the Special Financial
Grant from the Shaanxi Postdoctoral Science Foundation (Y.W.), the Clinical Research
Award of the First Affiliated Hospital of Xi’an Jiaotong University No. XJTU1AF-CRF-2017-021
(Y.W.), Grants 2016YFC1300104 and 2017YFC1307604 (J.-J.M.) from the Major Chronic
Non-communicable Disease Prevention and Control Research Key Project of the Ministry
of Science and Technology of China, and Grant 2017ZDXM-SF-107 (J.-J.M.) from the Key
Research Project of Shaanxi Province. The funders had no role in study design, data
collection and analysis, or preparation of the manuscript.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Processes
Subject:
Excretion
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Physiological Processes
Subject:
Excretion
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Acids
Subject:
Uric Acid
Subject:
Medicine and Health Sciences
Subject:
Vascular Medicine
Subject:
Blood Pressure
Subject:
Hypertension
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Renal Physiology
Subject:
Glomerular Filtration Rate
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Renal Physiology
Subject:
Glomerular Filtration Rate
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Urine
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Urine
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Urine
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Urine
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Disorders
Subject:
Diabetes Mellitus
Subject:
Medicine and Health Sciences
Subject:
Metabolic Disorders
Subject:
Diabetes Mellitus
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Lipids
Subject:
Cholesterol
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Biomarkers
Subject:
Creatinine
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