Assessment of different quantification metrics of [ <sup>18</sup>F]-NaF PET/CT images of patients with abdominal aortic aneurysm

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Abstract

Background

We aim to assess the spill-in effect and the benefit in quantitative accuracy for [ ¹⁸F]-NaF PET/CT imaging of abdominal aortic aneurysms (AAA) using the background correction (BC) technique.

Methods

Seventy-two datasets of patients diagnosed with AAA were reconstructed with ordered subset expectation maximization algorithm incorporating point spread function (PSF). Spill-in effect was investigated for the entire aneurysm (AAA), and part of the aneurysm excluding the region close to the bone (AAA _exc). Quantifications of PSF and PSF+BC images using different thresholds (% of max. SUV in target regions-of-interest) to derive target-to-background (TBR) values (TBR _max, TBR ₉₀, TBR ₇₀ and TBR ₅₀) were compared at 3 and 10 iterations.

Results

TBR differences were observed between AAA and AAA _exc due to spill-in effect from the bone into the aneurysm. TBR _max showed the highest sensitivity to the spill-in effect while TBR ₅₀ showed the least. The spill-in effect was reduced at 10 iterations compared to 3 iterations, but at the expense of reduced contrast-to-noise ratio (CNR). TBR ₅₀ yielded the best trade-off between increased CNR and reduced spill-in effect. PSF+BC method reduced TBR sensitivity to spill-in effect, especially at 3 iterations, compared to PSF ( P-value ≤ 0.05).

Conclusion

TBR ₅₀ is robust metric for reduced spill-in and increased CNR.

Electronic supplementary material

The online version of this article (10.1007/s12350-020-02220-2) contains supplementary material, which is available to authorized users.

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Author and article information

Contributors

Mercy I. Akerele: mercyoloniyo@yahoo.com

Charalampos Tsoumpas: c.tsoumpas@leeds.ac.uk

Journal

Journal ID (nlm-ta): J Nucl Cardiol

Journal ID (iso-abbrev): J Nucl Cardiol

Title: Journal of Nuclear Cardiology

Publisher: Springer International Publishing (Cham )

ISSN (Print): 1071-3581

ISSN (Electronic): 1532-6551

Publication date (Electronic): 17 June 2020

Publication date PMC-release: 17 June 2020

Publication date (Print): 2022

Volume: 29

Issue: 1

Pages: 251-261

Affiliations

[1 ]GRID grid.9909.9, ISNI 0000 0004 1936 8403, Biomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, , University of Leeds, ; Leeds, LS2 9NL UK

[2 ]GRID grid.4305.2, ISNI 0000 0004 1936 7988, British Heart Foundation Centre for Cardiovascular Science, , University of Edinburgh, ; Edinburgh, UK

[3 ]GRID grid.4305.2, ISNI 0000 0004 1936 7988, Edinburgh Imaging Facility, Queen’s Medical Research Institute, , University of Edinburgh, ; Edinburgh, UK

[4 ]GRID grid.5386.8, ISNI 000000041936877X, Division of Radiopharmaceutical Sciences, Department of Radiology, , Weil Cornell Medical College of Cornell University, ; New York, NY USA

[5 ]GRID grid.59734.3c, ISNI 0000 0001 0670 2351, Biomedical Engineering & Imaging Institute, , Icahn School of Medicine at Mount Sinai, ; New York, NY USA

[6 ]GRID grid.498414.4, ISNI 0000 0004 0548 3187, Invicro, ; London, UK

Article

Publisher ID: 2220

DOI: 10.1007/s12350-020-02220-2

PMC ID: 8873073

PubMed ID: 32557152

SO-VID: 453037a2-fc21-4ef5-9720-f20451f4e73c

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 20 February 2020

Date accepted : 26 May 2020

Custom metadata

ScienceOpen disciplines: Cardiovascular Medicine

Keywords: abdominal aortic aneurysm,spill-in effect,background correction,target-to-background ratio

Data availability:

ScienceOpen disciplines: Cardiovascular Medicine

Keywords: abdominal aortic aneurysm, spill-in effect, background correction, target-to-background ratio