Location, location, location! Rewiring IL-2 circuits defines context-specific outcomes.

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Abstract

Here, we highlight a recent publication by Whyte et al. that reveals diverse immune outcomes of interleukin (IL)-2 expression in distinct microenvironments. Their definition of context-dependent IL-2 networks paves the way for the development of tissue-specific therapies that enlist the potent immuno-modulatory activity of IL-2.

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Journal

Journal ID (iso-abbrev): Immunol Cell Biol

Title: Immunology and cell biology

Publisher: Wiley

ISSN (Electronic): 1440-1711

ISSN (Print): 0818-9641

Publication date (Electronic): Sep 2022

Volume: 100

Issue: 8

Affiliations

[1 ] The Walter and Eliza Hall Institute, Parkville, VIC, Australia.

[2 ] Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.

Article

DOI: 10.1111/imcb.12573

PubMed ID: 35848928

SO-VID: 456c0d6b-5fcf-497d-b1a9-aad84017a11f

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