Glucose promotes cell proliferation, glucose uptake and invasion in endometrial cancer cells via AMPK/mTOR/S6 and MAPK signaling.

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Abstract

Obesity and diabetes are well-known risk factors for the development of endometrial cancer. A high rate of aerobic glycolysis represents a key mechanism by which endometrial cancer cells consume glucose as its primary energy source. The up-regulated glycolytic pathway is a common therapeutic target whose inhibition has implications for anti-tumor activity in cancer cells. This study aimed to investigate the effect of various concentrations of glucose on cell proliferation in endometrial cancer.

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Author and article information

Journal

Journal ID (iso-abbrev): Gynecol. Oncol.

Title: Gynecologic oncology

Publisher: Elsevier BV

ISSN (Electronic): 1095-6859

ISSN (Print): 0090-8258

Publication date (Electronic): Sep 2015

Volume: 138

Issue: 3

Affiliations

[1 ] Department of Surgical Oncology, Shandong Cancer Hospital and Institute, Jinan, China; Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

[2 ] Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, China; Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Jinan, China.

[3 ] Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

[4 ] Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Jinan, China.

[5 ] Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: czhou@med.unc.edu.

[6 ] Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: victoria_baejump@med.unc.edu.

Article

Publisher Item ID: S0090-8258(15)30057-3 Mid ID: NIHMS707447

DOI: 10.1016/j.ygyno.2015.06.036

PMC ID: 4672629

PubMed ID: 26135947

SO-VID: 45cc886c-249c-4469-9ed0-15fc89f807cb

History

Keywords: Endometrial cancer,Glucose,Glycolysis,Invasion

Data availability:

Keywords: Endometrial cancer, Glucose, Glycolysis, Invasion

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