0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Neurosecretion of Human Hypothalamic Immunoreactive β-Endorphin: In vitro Regulation by Dopamine

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          An in vitro perifusion system was used to investigate immunoreactive β-endorphin (β-END-I) release from adult human hypothalami in response to dopamine (DA) and the DA receptor antagonist haloperidol (HAL). Administration of a 1 µM pulse of DA consistently elicited a mean (±SE) 88 ± 9% increase (p< 0.05, n = 5) in β-END-I release, whereas 1 µM HAL had no effect. Administration of 1 µM DA during three perifusions in which 1 µM HALwas added to the medium failed to alter basal β-END-I release. In contrast, DA did evoke an acute 230 + 31% increase (p< 0.05) in β-END-I release during three matching perifusions with medium containing the α-adrenergic antagonist phentolamine. These studies demonstrate that DA can stimulate in vitro release of β-END-I from the adult human hypothalamus by a DA receptor mediated mechanism.

          Related collections

          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1987
          1987
          02 April 2008
          : 45
          : 3
          : 197-200
          Affiliations
          Departments of Reproductive Medicine and Pathology, University of California, San Diego, La Jolla, Calif., USA
          Article
          124725 Neuroendocrinology 1987;45:197–200
          10.1159/000124725
          2951610
          © 1987 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Original Paper

          Comments

          Comment on this article