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Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.
Javier Fernández
1 ,
José M Alonso ,
José I Andrés ,
José M Cid ,
Adolfo Díaz ,
Laura Iturrino ,
Pilar Gil ,
Anton Megens ,
Victor K Sipido ,
Andrés A Trabanco
Mar 24 2005
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Abstract
A series of novel tetracyclic tetrahydrofuran derivatives was prepared and evaluated for its potential psychotropic properties. In vitro affinities for multiple dopaminergic, serotonergic, alpha-adrenergic, and histamine receptors and for the norepinephrine transporter as well as the ED(50) values obtained in some in vivo assays for antipsychotic, anxiolytic, and antidepressant potential are reported. Compounds (-)-1, (-)-8d, and (+)-8d have been identified as potential broad-spectrum psychotropic agents.