For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
20
views
61
references
 Top references
cited by
61
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      668
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Respiratory syncytial virus (RSV) and its propensity for causing bronchiolitis

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Infants and young children with acute onset of wheezing and reduced respiratory airflows are often diagnosed with obstruction and inflammation of the small bronchiolar airways, ie bronchiolitis. The most common aetological agents causing bronchiolitis in young children are the respiratory viruses, and of the commonly encountered respiratory viruses, respiratory syncytial virus ( RSV) has a propensity for causing bronchiolitis. Indeed, RSV bronchiolitis remains the major reason why previously healthy infants are admitted to hospital. Why RSV infection is such a predominant cause of bronchiolitis is the subject of this review. By reviewing the available histopathology of RSV bronchiolitis, both in humans and relevant animal models, we identify hallmark features of RSV infection of the distal airways and focus attention on the consequences of columnar cell cytopathology occurring in the bronchioles, which directly impacts the development of bronchiolar obstruction, inflammation and disease. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

          Related collections

          Most cited references61

          • Record: found
          • Abstract: not found
          • Article: not found

          Respiratory syncytial virus and parainfluenza virus.

          C Hall (2001)
          Article 0 comments Cited 344 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Bronchiolitis-associated hospitalizations among US children, 1980-1996.

            Lei Liu, P. Newman, Ashley Holman … (1999)
            Respiratory syncytial virus (RSV) causes more lower respiratory tract infections, often manifested as bronchiolitis, among young children than any other pathogen. Few national estimates exist of the hospitalizations attributable to RSV, and recent advances in prophylaxis warrant an update of these estimates. To describe rates of bronchiolitis-associated hospitalizations and to estimate current hospitalizations associated with RSV infection. Descriptive analysis of US National Hospital Discharge Survey data from 1980 through 1996. Children younger than 5 years who were hospitalized in short-stay, non-federal hospitals for bronchiolitis. Bronchiolitis-associated hospitalization rates by age and year. During the 17-year study period, an estimated 1.65 million hospitalizations for bronchiolitis occurred among children younger than 5 years, accounting for 7.0 million inpatient days. Fifty-seven percent of these hospitalizations occurred among children younger than 6 months and 81 % among those younger than 1 year. Among children younger than 1 year, annual bronchiolitis hospitalization rates increased 2.4-fold, from 12.9 per 1000 in 1980 to 31.2 per 1000 in 1996. During 1988-1996, infant hospitalization rates for bronchiolitis increased significantly (P for trend <.001), while hospitalization rates for lower respiratory tract diseases excluding bronchiolitis did not vary significantly (P for trend = .20). The proportion of hospitalizations for lower respiratory tract illnesses among children younger than 1 year associated with bronchiolitis increased from 22.2% in 1980 to 47.4% in 1996; among total hospitalizations, this proportion increased from 5.4% to 16.4%. Averaging bronchiolitis hospitalizations during 1994-1996 and assuming that RSV was the etiologic agent in 50% to 80% of November through April hospitalizations, an estimated 51, 240 to 81, 985 annual bronchiolitis hospitalizations among children younger than 1 year were related to RSV infection. During 1980-1996, rates of hospitalization of infants with bronchiolitis increased substantially, as did the proportion of total and lower respiratory tract hospitalizations associated with bronchiolitis. Annual bronchiolitis hospitalizations associated with RSV infection among infants may be greater than previous estimates for RSV bronchiolitis and pneumonia hospitalizations combined.
            Article 0 comments Cited 267 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Human and avian influenza viruses target different cell types in cultures of human airway epithelium.

              Mikhail N Matrosovich, Tatyana Y Matrosovich, Thomas Scott Gray … (2004)
              The recent human infections caused by H5N1, H9N2, and H7N7 avian influenza viruses highlighted the continuous threat of new pathogenic influenza viruses emerging from a natural reservoir in birds. It is generally believed that replication of avian influenza viruses in humans is restricted by a poor fit of these viruses to cellular receptors and extracellular inhibitors in the human respiratory tract. However, detailed mechanisms of this restriction remain obscure. Here, using cultures of differentiated human airway epithelial cells, we demonstrated that influenza viruses enter the airway epithelium through specific target cells and that there were striking differences in this respect between human and avian viruses. During the course of a single-cycle infection, human viruses preferentially infected nonciliated cells, whereas avian viruses as well as the egg-adapted human virus variant with an avian virus-like receptor specificity mainly infected ciliated cells. This pattern correlated with the predominant localization of receptors for human viruses (2-6-linked sialic acids) on nonciliated cells and of receptors for avian viruses (2-3-linked sialic acids) on ciliated cells. These findings suggest that although avian influenza viruses can infect human airway epithelium, their replication may be limited by a nonoptimal cellular tropism. Our data throw light on the mechanisms of generation of pandemic viruses from their avian progenitors and open avenues for cell level-oriented studies on the replication and pathogenicity of influenza virus in humans.
              Article 0 comments Cited 251 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): J Pathol
                Journal ID (iso-abbrev): J. Pathol
                Journal ID (doi): 10.1002/(ISSN)1096-9896
                Journal ID (publisher-id): PATH
                Title: The Journal of Pathology
                Publisher: John Wiley & Sons, Ltd (Chichester, UK )
                ISSN (Print): 0022-3417
                ISSN (Electronic): 1096-9896
                Publication date (Print): January 2015
                Publication date (Electronic): 11 December 2014
                Volume: 235
                Issue: 2 , Viruses and Disease ( doiID: 10.1002/path.2015.235.issue-2 )
                Pages: 266-276
                Affiliations
                [ 1 ] Department of Microbiology and Immunology University of North Carolina Chapel Hill NC USA
                [ 2 ] Department of Paediatrics, Microbiology, Immunology and Biochemistry, Division of Infectious Diseases University of Tennessee School of Medicine, and Molecular Diagnostics and Virology Laboratories, Le Bonheur Children's Hospital Memphis TN USA
                Author notes
                [*] [* ]Correspondence to: RJ Pickles, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 7021 Thurston Bowles, Chapel Hill, NC 27599‐7248, USA. E‐mail: branston@ 123456med.unc.edu
                Article
                Publisher ID: PATH4462
                DOI: 10.1002/path.4462
                PMC ID: 5638117
                PubMed ID: 25302625
                SO-VID: 4663eaa2-ef4b-499f-a606-29dd81286856
                Copyright © Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd
                License:

                This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

                History
                Date received : 24 September 2014
                Date revision received : 24 September 2014
                Date accepted : 05 October 2014
                Page count
                Pages: 11
                Categories
                Subject: Invited Review
                Subject: Invited Reviews
                Custom metadata
                source-schema-version-number 2.0
                cover-date January 2015
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.0 mode:remove_FC converted:15.04.2020

                ScienceOpen disciplines: Pathology
                Keywords: respiratory syncytial virus,airway obstruction,bronchiolitis,acute lung disease
                Data availability:
                ScienceOpen disciplines: Pathology
                Keywords: respiratory syncytial virus, airway obstruction, bronchiolitis, acute lung disease

                Comments

                Comment on this article

                scite_

                Similar content668

                See all similar

                Cited by60

                See all cited by

                Most referenced authors947

                See all reference authors