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      From The Cover: The human brain is intrinsically organized into dynamic, anticorrelated functional networks

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          Abstract

          During performance of attention-demanding cognitive tasks, certain regions of the brain routinely increase activity, whereas others routinely decrease activity. In this study, we investigate the extent to which this task-related dichotomy is represented intrinsically in the resting human brain through examination of spontaneous fluctuations in the functional MRI blood oxygen level-dependent signal. We identify two diametrically opposed, widely distributed brain networks on the basis of both spontaneous correlations within each network and anticorrelations between networks. One network consists of regions routinely exhibiting task-related activations and the other of regions routinely exhibiting task-related deactivations. This intrinsic organization, featuring the presence of anticorrelated networks in the absence of overt task performance, provides a critical context in which to understand brain function. We suggest that both task-driven neuronal responses and behavior are reflections of this dynamic, ongoing, functional organization of the brain.

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          Author and article information

          Journal
          Proceedings of the National Academy of Sciences
          Proceedings of the National Academy of Sciences
          Proceedings of the National Academy of Sciences
          0027-8424
          1091-6490
          July 05 2005
          July 05 2005
          June 23 2005
          July 05 2005
          : 102
          : 27
          : 9673-9678
          Article
          10.1073/pnas.0504136102
          1157105
          15976020
          468ddfba-c344-483c-a47b-fbc984886441
          © 2005
          History

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