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      Mammary gland development: cell fate specification, stem cells and the microenvironment.

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          Abstract

          The development of the mammary gland is unique: the final stages of development occur postnatally at puberty under the influence of hormonal cues. Furthermore, during the life of the female, the mammary gland can undergo many rounds of expansion and proliferation. The mammary gland thus provides an excellent model for studying the 'stem/progenitor' cells that allow this repeated expansion and renewal. In this Review, we provide an overview of the different cell types that constitute the mammary gland, and discuss how these cell types arise and differentiate. As cellular differentiation cannot occur without proper signals, we also describe how the tissue microenvironment influences mammary gland development.

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          Author and article information

          Journal
          Development
          Development (Cambridge, England)
          1477-9129
          0950-1991
          Mar 15 2015
          : 142
          : 6
          Affiliations
          [1 ] Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA.
          [2 ] Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA mjbissell@lbl.gov.
          Article
          142/6/1028
          10.1242/dev.087643
          25758218
          © 2015. Published by The Company of Biologists Ltd.

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