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      Stopping the fat: Repurposing an antidepressant for cancer treatment

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      Author(s): 1 , 1 ,
      Publication date (Electronic):
      Journal: The Journal of Experimental Medicine
      Publisher: Rockefeller University Press

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          Abstract

          In this issue of JEM, Chu and An et al. describe the role of the tricyclic antidepressant nortriptyline in inhibition of fatty acid uptake. Nortriptyline promotes cell acidification and suppresses macropinocytosis, providing a link between fatty acid uptake and tumor progression.

          Abstract

          In this issue of JEM, Chu and An et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20221316) describe the role of the tricyclic antidepressant nortriptyline in inhibition of fatty acid uptake. Nortriptyline promotes cell acidification and suppresses macropinocytosis, providing a link between fatty acid uptake and tumor progression.

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          Nortriptyline

          G. Merwar, J.R. GIBBONS, S.A. Hosseini … (2022)
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            Author and article information

            Journal
            Journal ID (nlm-ta): J Exp Med
            Journal ID (iso-abbrev): J Exp Med
            Journal ID (publisher-id): jem
            Title: The Journal of Experimental Medicine
            Publisher: Rockefeller University Press
            ISSN (Print): 0022-1007
            ISSN (Electronic): 1540-9538
            Publication date Collection: 06 March 2023
            Publication date (Electronic): 02 February 2023
            Volume: 220
            Issue: 3
            Electronic Location Identifier: e20222097
            Affiliations
            [1 ]Cell and Molecular Biology of Cancer Program, National Cancer Institute Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute ( https://ror.org/03m1g2s55) , La Jolla, CA, USA
            Author notes
            Author information
            https://orcid.org/0000-0002-7884-9210
            Article
            Publisher ID: jem.20222097
            DOI: 10.1084/jem.20222097
            PMC ID: 9929654
            PubMed ID: 36729077
            SO-VID: 475444af-3e75-47d9-a5bd-65cf1e811f8d
            Copyright © © 2023 Bhullar and Commisso
            License:

            This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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            Subject: Insights
            Subject: Solid Tumors

            ScienceOpen disciplines: Medicine
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            ScienceOpen disciplines: Medicine

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