Prolonged Correction of Serum Phosphorus in Adults With X-Linked Hypophosphatemia Using Monthly Doses of KRN23.

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Abstract

In X-linked hypophosphatemia (XLH), elevated fibroblast growth factor 23 (FGF23) decreases the renal tubular maximum reabsorption rate of phosphate/glomerular filtration rate (TmP/GFR) and serum inorganic phosphorus (Pi), resulting in rickets and/or osteomalacia.

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Journal

Journal ID (iso-abbrev): J. Clin. Endocrinol. Metab.

Title: The Journal of clinical endocrinology and metabolism

ISSN (Electronic): 1945-7197

ISSN (Print): 0021-972X

Publication date (Electronic): Jul 2015

Volume: 100

Issue: 7

Affiliations

[1 ] Indiana University School of Medicine (E.A.I., M.P.), Indianapolis, Indiana 46202; Kyowa Hakko Kirin Pharma Inc (X.Z., M.A.K., T.I., M.V., J.S.H.), Princeton, New Jersey 08540; Houston Methodist Hospital (M.D.R.), Houston, Texas 77030; Duke University Medical Center (T.J.W.), Durham, North Carolina 27710; Shriners Hospital for Children (F.H.G.), Montreal, Quebec H3G 1A6, Canada; University of California (A.A.P.), San Francisco, California 94143; and Yale Center for X-Linked Hypophosphatemia (K.I., T.O.C.), Yale University School of Medicine, New Haven, Connecticut 06520.

Article

DOI: 10.1210/jc.2015-1551

PMC ID: 4495171

PubMed ID: 25919461

SO-VID: 479372d9-2a17-4464-b1eb-1a1ddc8c7a1f

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