Improving Adequacy of Small Biopsy and Fine-Needle Aspiration Specimens for Molecular Testing by Next-Generation Sequencing in Patients With Lung Cancer: A Quality Improvement Study at Dartmouth-Hitchcock Medical Center.

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Abstract

- At our medical center, cytopathologists perform rapid on-site evaluation for specimen adequacy of fine-needle aspiration and touch imprint of needle core biopsy lung cancer samples. Two years ago the molecular diagnostics laboratory at our institution changed to next-generation sequencing using the Ion Torrent PGM and the 50-gene AmpliSeq Cancer Hotspot Panel v2 for analyzing mutations in a 50-gene cancer hot spot panel. This was associated with a dramatic fall in adequacy rate (68%).

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Journal

Journal ID (iso-abbrev): Arch. Pathol. Lab. Med.

Title: Archives of pathology & laboratory medicine

Publisher: Archives of Pathology and Laboratory Medicine

ISSN (Electronic): 1543-2165

ISSN (Print): 0003-9985

Publication date (Electronic): Mar 2017

Volume: 141

Issue: 3

Affiliations

[1 ] From the Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire. Dr Padmanabhan is now with the Department of Pathology, Baylor College of Medicine, Ben Taub General Hospital, Houston, Texas.

Article

DOI: 10.5858/arpa.2016-0096-OA

PubMed ID: 27763790

SO-VID: 481374f7-c58d-4c4f-8f3c-869578ee965d

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