Blog
About

11
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      The X family portrait: Structural insights into biological functions of X family polymerases

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The mammalian family X DNA polymerases (DNA polymerases beta, lambda, mu, and TdT) contribute to base excision repair and double-strand break repair by virtue of their ability to fill short gaps in DNA. Structural information now exists for all four of these enzymes, making this the first mammalian polymerase family whose structural portrait is complete. Here we consider how distinctive structural features of these enzymes contribute to their biological functions in vivo.

          Related collections

          Author and article information

          Journal
          DNA Repair
          DNA Repair
          Elsevier BV
          15687864
          December 2007
          December 2007
          : 6
          : 12
          : 1709-1725
          Article
          10.1016/j.dnarep.2007.05.009
          2128704
          17631059
          © 2007

          https://www.elsevier.com/tdm/userlicense/1.0/

          Comments

          Comment on this article