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      Insulin temporal sensitivity and its signaling pathway in the rat pineal gland.

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          Abstract

          In our previous work, we reported that the insulin potentiating effect on melatonin synthesis is regulated by a post-transcriptional mechanism. However, the major proteins of the insulin signaling pathway (ISP) and the possible pathway component recruited on the potentiating effect of insulin had not been characterized. A second question raised was whether windows of sensitivity to insulin exist in the pineal gland due to insulin rhythmic secretion pattern.

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          Author and article information

          Journal
          Life Sci.
          Life sciences
          Elsevier BV
          1879-0631
          0024-3205
          Jul 31 2010
          : 87
          : 5-6
          Affiliations
          [1 ] University of São Paulo, Institute of Biomedical Sciences-I, Department of Physiology and Biophysics, São Paulo, SP, Brazil.
          Article
          S0024-3205(10)00246-8
          10.1016/j.lfs.2010.06.005
          20600146
          48d5f86b-1bed-415c-aa9c-59364002def0
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