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      Comparative Immunocytochemical Localization of Corticotropin Releasing Factor (CRF-41) and Neurohypophysial Peptides in the Brain of Brattleboro and Long-Evans Rats

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          The localization of CRF-41 related peptide was studied in the brain and posterior pituitary of the homozygous rats for the inherited diabetes insipidus (Brattleboro strain, DI) and of the Long-Evans rats (LE) as control. It was compared to the distribution of vasopressin (AVP), oxytocin (OXY) and OXY-neurophysin (N I). In both strains, CRF-41 was identified in two morphologically distinct systems:one was a hypothalamoneurohypophysial system simultaneously containing CRF-41, OXY and N I; the other was a hypothalamoinfundibular system carrying CRF-41 only. CRF containing neurons were located in the periventricular area of the anterior hypothalamus, in the retrochiasmatic part of the supraoptic nuclei (SON) and, for some of them, in the antechiasmatic part of SON. CRF immunostainings were enhanced by colchicine treatment in LE rats and by DDAVP therapy in DI rats.

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          Author and article information

          S. Karger AG
          27 March 2008
          : 37
          : 1
          : 64-72
          aFaculté de Médecine, Laboratoire d’Histologie A, Vandœuvre-les-Nancy, France; bGroupe de Recherche en Endocrinologie Moléculaire, Faculté des Sciences de Rouen, Mont-Saint-Aignan, France; cVeterans Administration Medical Center, Tulane University, New Orleans, La., USA
          123517 Neuroendocrinology 1983;37:64–72
          © 1983 S. Karger AG, Basel

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          Pages: 9
          Original Paper


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