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      Benchmarks for ethically credible partnerships between industry and academic health centers: beyond disclosure of financial conflicts of interest

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          Abstract

          Relationships between industry and university-based researchers have been commonplace for decades and have received notable attention concerning the conflicts of interest these relationships may harbor. While new efforts are being made to update conflict of interest policies and make industry relationships with academia more transparent, the development of broader institutional partnerships between industry and academic health centers challenges the efficacy of current policy to effectively manage these innovative partnerships. In this paper, we argue that existing strategies to reduce conflicts of interest are not sufficient to address the emerging models of industry-academic partnerships because they focus too narrowly on financial matters and are not comprehensive enough to mitigate all ethical risk. Moreover, conflict-of-interest strategies are not designed to promote best practices nor the scientific and social benefits of academic-industry collaboration. We propose a framework of principles and benchmarks for “ethically credible partnerships” between industry and academic health centers and describe how this framework may provide a practical and comprehensive approach for designing and evaluating such partnerships.

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          Most cited references38

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          Academic engagement and commercialisation: A review of the literature on university–industry relations

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            What makes clinical research in developing countries ethical? The benchmarks of ethical research.

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              Scope and impact of financial conflicts of interest in biomedical research: a systematic review.

              Despite increasing awareness about the potential impact of financial conflicts of interest on biomedical research, no comprehensive synthesis of the body of evidence relating to financial conflicts of interest has been performed. To review original, quantitative studies on the extent, impact, and management of financial conflicts of interest in biomedical research. Studies were identified by searching MEDLINE (January 1980-October 2002), the Web of Science citation database, references of articles, letters, commentaries, editorials, and books and by contacting experts. All English-language studies containing original, quantitative data on financial relationships among industry, scientific investigators, and academic institutions were included. A total of 1664 citations were screened, 144 potentially eligible full articles were retrieved, and 37 studies met our inclusion criteria. One investigator (J.E.B.) extracted data from each of the 37 studies. The main outcomes were the prevalence of specific types of industry relationships, the relation between industry sponsorship and study outcome or investigator behavior, and the process for disclosure, review, and management of financial conflicts of interest. Approximately one fourth of investigators have industry affiliations, and roughly two thirds of academic institutions hold equity in start-ups that sponsor research performed at the same institutions. Eight articles, which together evaluated 1140 original studies, assessed the relation between industry sponsorship and outcome in original research. Aggregating the results of these articles showed a statistically significant association between industry sponsorship and pro-industry conclusions (pooled Mantel-Haenszel odds ratio, 3.60; 95% confidence interval, 2.63-4.91). Industry sponsorship was also associated with restrictions on publication and data sharing. The approach to managing financial conflicts varied substantially across academic institutions and peer-reviewed journals. Financial relationships among industry, scientific investigators, and academic institutions are widespread. Conflicts of interest arising from these ties can influence biomedical research in important ways.
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                Author and article information

                Contributors
                emeslin@iu.edu
                jbrager@iupui.edu
                phschwar@iu.edu
                kquaid@iu.edu
                mgaffney@iupui.edu
                jonduke@regenstrief.org
                wtierney@iupui.edu
                Journal
                Clin Transl Med
                Clin Transl Med
                Clinical and Translational Medicine
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                2001-1326
                14 December 2015
                14 December 2015
                2015
                : 4
                : 36
                Affiliations
                [ ]Indiana University Center for Bioethics, 410 West 10th Street, Indianapolis, IN 46202 USA
                [ ]Regenstrief Institute Inc., 410 West 10th Street, Indianapolis, IN 46202 USA
                Article
                77
                10.1186/s40169-015-0077-y
                4678144
                26668063
                48fc2618-624d-4d28-a832-8d78bb501146
                © Meslin et al. 2015

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

                History
                : 30 September 2015
                : 29 November 2015
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/100006108, National Center for Advancing Translational Sciences;
                Award ID: UL1TR001108
                Funded by: FundRef http://dx.doi.org/10.13039/100000061, Fogarty International Center;
                Award ID: 2 R25 TW006070-05
                Award Recipient :
                Funded by: Regenstrief Institute
                Categories
                Perspective
                Custom metadata
                © The Author(s) 2015

                Medicine
                academic-industry partnerships,collaboration,ethics,benchmarks,cooperative behavior,academic-industry relationships,conflict of interest,academic health centers,industry

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