Sildenafil and bosentan improve arterial oxygenation during acute hypoxic exercise: a controlled laboratory trial.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Sildenafil and, recently, bosentan have been reported to increase arterial saturation and exercise capacity at altitude. The mechanisms behind this are still poorly defined but may be related to attenuation of hypoxic pulmonary vasoconstriction (HPV) and improved gas exchange. This study was designed to examine and compare the effect of sildenafil and bosentan on pulmonary gas exchange during acute hypoxic exercise in a controlled laboratory setting.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Wilderness Environ Med

Title: Wilderness & environmental medicine

ISSN (Electronic): 1545-1534

ISSN (Print): 1080-6032

Publication date (Electronic): Sep 2011

Volume: 22

Issue: 3

Affiliations

[1 ] Center for Cardiovascular and Respiratory Sciences, Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506, USA. molfert@hsc.wvu.edu

Article

Publisher Item ID: S1080-6032(11)00078-0

DOI: 10.1016/j.wem.2011.03.004

PubMed ID: 21723164

SO-VID: 494a67c8-c7ab-4b97-9b19-fff802c99e3a

History

Data availability:

Comments

Comment on this article

scite_

Cited by 7

See all cited by