Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir Combination Treatment in Patients with HIV/HCV Co-Infection: Results of an Italian Compassionate Use Program.

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Abstract

Patients co-infected with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are at high risk of liver disease progression. We report a favorable safety profile and SVR12 rates of 96.7% among HIV/HCV co-infected patients participating in an Italian compassionate-use program of ombitasvir/paritaprevir/ritonavir + dasabuvir (OBV/PTV/r + DSV) ± ribavirin (RBV).

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Journal

Journal ID (iso-abbrev): Clin. Infect. Dis.

Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1537-6591

ISSN (Print): 1058-4838

Publication date (Electronic): March 01 2017

Volume: 64

Issue: 5

Affiliations

[1 ] Clinical Infectious Diseases, Department. of Systems Medicine, Tor Vergata University, Rome, Italy.

[2 ] Clinical Department, National Institute for Infectious Diseases, INMI "L. Spallanzani″, Rome, Italy.

[3 ] Department of Biomedical and Clinical Science, University of Milan,Milan, Italy.

[4 ] Department of Infectious Diseases, ASST Fatebenefratelli Sacco, Milan, Italy, and School of Clinical Medicine, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa.

[5 ] Infectious Disease Clinic, IRCCS University Hospital, San Martino IST, Genova, Italy.

[6 ] Institute of Infectious Disease, University of Bari, Bari, Italy.

[7 ] Division of Infectious and Tropical Diseases, IRCCS Policlinico San Matteo, Pavia, Italy.

[8 ] Infectious Diseases Clinic, University Hospital, Modena, Italy.

[9 ] Department of Internal and Specialty Medicine University Infectious Diseases Unit, AOU Senese, Siena, Italy.

[10 ] Department of Infectious and Tropical Diseases, University Hospital, Padova, Italy.

[11 ] Department of Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.

[12 ] Department of Clinical Medicine, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

[13 ] Clinic of Infectious and Tropical Diseases, Department of Health Sciences, University of Milan, Milan, Italy.

[14 ] Infectious Diseases Unit, Sapienza University of Rome, Latina, Italy, and Department of Public Health and Infectious Diseases, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

[15 ] Unit of Infectious Diseases, University of Turin, Department of Medical Sciences, "Amedeo di Savoia″ Hospital, Turin, Italy.

[16 ] Division of Infectious Diseases, AO Papa Giovanni XXIII, Bergamo, Italy.

[17 ] Division of Infectious Diseases, AO Niguarda Ca' Granda Hospital, Milan, Italy.

[18 ] Division of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy.

[19 ] Division of Infectious Diseases, Department of Internal Medicine, "San Gerardo″ Hospital, University of Milan-Bicocca, Milan, Italy.

[20 ] First Division of Infectious Diseases, S. Giovanni di Dio e Ruggi d'Aragona Hospital, Salerno, Italy.

[21 ] Division of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, Catania, Italy.

[22 ] Infectious Diseases Unit, Department of Biomedical Sciences and Public Health, Marche Polytechnic University c/o Ospedali Riuniti, Ancona, Italy.

[23 ] Infectious Disease Unit, Pescara General Hospital, Pescara, Italy.

[24 ] Department of Public Health and Infectious Diseases, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

[25 ] III U.O.C. P.O. Cotugno, AORN Ospedali dei Colli, Naples, Italy.

[26 ] Clinical Infectious Diseases, Sant'Andrea Hospital - Sapienza University of Rome, Rome, Italy.

[27 ] Unit of Infectious Diseases, University Hospital of Ferrara, Ferrara, Italy.

Article

Publisher Item ID: ciw846

DOI: 10.1093/cid/ciw846

PubMed ID: 28011605

SO-VID: 4a37557f-c58d-4715-b3fb-b42087dca12a

History

Keywords: DAA,HIV/HCV co-infection,IFN-free,anti-HCV therapy,antiviral therapy

Data availability:

Keywords: DAA, HIV/HCV co-infection, IFN-free, anti-HCV therapy, antiviral therapy

Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir Combination Treatment in Patients with HIV/HCV Co-Infection: Results of an Italian Compassionate Use Program.

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