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Abstract
A 53-year-old man with a history of diabetes presented with weakness in both legs
accompanied by numbness and pain. Eight months previously, he had a pelvic mass that
caused pain during defecation and was diagnosed as having diffuse large B cell lymphoma.
He received 6 cycles of R-CHOP chemotherapy and field radiation therapy (dose, 44
Gy). No hypermetabolic lesions were detected by positron emission tomography (PET)-computed
tomography scanning. Two months later, he presented with the above neurological manifestations,
including right facial palsy. Brain and spine magnetic resonance imaging did not find
any evidence of lymphoma involvement. A cerebrospinal fluid (CSF) cytological study
was also negative. A nerve conduction study showed delayed peak latencies and reduced
amplitudes of sensory nerve action potentials in both the sural nerves. Reduced amplitude
of combined motor action potential and conduction velocities were identified in both
the deep peroneal nerves. The patient had a history of diabetes and hepatitis C, but
because of sensorimotor nerve involvement, polyneuropathy associated with underlying
systemic disease or chemotherapy toxicity was not diagnosed. Sequential 18F-fluoro-2-deoxy-D-glucose
(FDG) PET images showed increased 18F-FDG uptake (SUVmax, 4.11) along the bilateral
lumbosacral plexus (arrow). A second CSF study revealed malignant lymphoma cells (A,
B).
Publisher:
Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation;
Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and
Hemostasis
ISSN
(Print):
2287-979X
ISSN
(Electronic):
2288-0011
Publication date
(Print):
June
2014
Publication date
(Electronic):
25
June
2014
Volume: 49
Issue: 2
Page: 83
Affiliations
Division of Hematology-Oncology, Department of Internal Medicine, Yeouido St. Mary's
Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
Author notes
Correspondence to Chi Wha Han, M.D., Department of Internal Medicine, St. Mary's Hospital,
10, 63-ro, Yeongdeungpo-gu, Seoul 150-713, Korea,
cwhan@
123456unitel.co.kr
This is an Open Access article distributed under the terms of the Creative Commons
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