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Abstract
MmP1 (Morganella morganii phage 1) is a lytic bacteriophage newly isolated from the
host bacterium M. morganii. The entire genome was sequenced, and final assembly yielded
a 38,234bp linear double-stranded DNA (dsDNA) with a G+C content of 46.5%. In the
MmP1 genome, 49 putative genes, 10 putative promoters and 2 predicted sigma-independent
terminators were determined through bioinformatic analysis. A striking feature of
the MmP1 genome is its high degree of similarity to the T7 group of phages. All of
the 49 predicted genes exist on the same DNA strand, and functions were assigned to
35 genes based on the similarity of the homologues deposited in GenBank, which share
30-80% identity to their counterparts in T7-like phages. The analyses of MmP1 using
CoreGenes, phylogenetic tree of RNA polymerase and structural proteins have demonstrated
that bacteriophage MmP1 should be assigned as a new member of T7-like phages but as
a relatively distant member of this family. This is the first report that a T7-like
phage adaptively parasitizes in M. morganii, and this will advance our understanding
of biodiversity and adaptive evolution of T7-like phages.