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      Sperm motility loss induced by gossypol: relation with OH. scavengers, motile stimulators and malondialdehyde production.

      Biochemical and Biophysical Research Communications

      pharmacology, Theophylline, drug effects, Sperm Motility, Rats, Mannitol, metabolism, Malondialdehyde, Male, Gossypol, Free Radical Scavengers, Animals, Aerobiosis

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          Abstract

          Aerobic incubation of rat spermatozoa in a balanced salt solution containing 10 microM of gossypol produced a loss of sperm motility. This effect was not reverted by the presence of 25 mM Theophylline, a well-known stimulant of motility, but was significantly diminished by the addition of 10 mM Mannitol. As mannitol is a superoxide scavenger and we found a close correlation between the loss of sperm motility and the malondialdehyde production, we concluded that gossypol affect rat spermatozoa by producing a peroxidative breakdown of membrane phospholipids.

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          Journal
          8216260
          10.1006/bbrc.1993.2183

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