The other day, we oversaw a seminar on pain management for a local consumer pain group,
where all consumers (patients) in attendance were experiencing chronic, persistent
spinal pain. Each person had a unique story, and their experience and perceived cause
of their pain differed. The quality of life in all these consumers was markedly reduced,
which was the only clear similarity, confirming that there may be some similarities
in the pain experience, but the pain experience was more often unique and individual.
These consumers’ criticisms of care services were consistent, however, with dissatisfaction
with their access to care and overall management of their pain. They described variable
and often difficult access, limited continuity of care, they were often not taken
seriously by health care providers, they received scant information about chronic
pain and its prognosis and there were often noteworthy variations in the treatment
they received. We agree that these criticisms are commonplace and a frequent gripe
directed at health care practitioners about the “system.”1 Moreover, the problems
associated with care delivery are confounded by a number of patient/consumer factors,
such as lifestyle habits, nutrition, body weight, depression, health literacy, geographical
isolation and poor socioeconomic conditions, making the management of persistent pain
even more complicated.2 There is no doubt that, in the future, matching the care service
and treatment with the individual patient will become an essential component of care
services, as has been implied in published research.3–6
Health care practitioners involved in the triage and management of patients with persistent
spinal pain will need to become more vigilant about individualizing and coordinating
care for each patient, to achieve the best possible outcomes. For example, Cecchi
et al concluded that patients with chronic (persistent) lower baseline pain (LBP)-related
disability predicted “nonresponse” to standard physiotherapy, but not to spinal manipulation
(an intervention commonly employed by chiropractors7–9), implying that spinal manipulation
should be considered as a first-line conservative treatment.9 We note that spinal
manipulation is now suggested as the first-line intervention by Deyo,10 since not
a single study examined in a recent systematic review found that spinal manipulation
was less effective than conventional care.11 Garcia et al,12 conversely, showed that
high pain intensity may be an important treatment effect modifier for patients with
chronic low back pain receiving Mckenzie therapy (a treatment frequently used by physiotherapists).
These examples demonstrate the importance of matching treatments with the characteristics
of the patient.
Similarly, identifying potential pain generators using diagnostic low-risk interventional
pain procedures by precise anatomical instillation of local anesthetics informs the
probability of subsequent therapeutic low-risk interventional pain procedures providing
medium- to long-term pain relief for that individual. The potential to provide a therapeutic
window, for months or years, can enable individuals to continue with evidence-informed
behavioral change to achieve the patient’s short- and long-term goals. Interventional
pain procedures are rarely performed in isolation because the procedure is only one
part of a broader pain management plan.
The person in pain, prior to considering an interventional pain procedure, is ideally
engaged in their own “prehabilitation,” which is the process of enhancing functional
capacity of the individual to enable him or her to recover more quickly following
a procedure.13 We suggest that the sequence of interventions first involves patient
assessment (history, examination, investigations, screening questionnaires, information
from previous health care professionals), from which follows pain options that are
relevant and available to the individual patient, which results in a pain management
plan that is agreed and understood by both the patient (and their significant others)
and treating practitioner and communicated to the other health care professionals
(coaches). If a person in pain does not currently have a well-organized team providing
evidence-based care, then their medical service will need to offer suggestions and
coordinate local available options to form a virtual health care pain team. Figure
1 flow chart, is an example of the process of care service provision and the patient
journey for the management of chronic spinal pain. Although interventional pain procedures
have been utilized for many decades, it is not easy to find precise definitions. Specifically,
the distinction between diagnostic and therapeutic procedures is often opaque, and
so we have provided our definitions to reduce miscommunication between health care
professionals (definitions are listed at the end of this article).
We would like to draw attention to behavioral changes such as non-sweating movements
including real-time imaging for retraining multifidus and transversus abdominis and
daily walking, and mindfulness which may all play a role in reducing fear, anxiety
and threat.14,15 We postulate increasing control and reducing threat, thereby reducing
the threat value of pain, can reduce the “other changeable pain” called alloplastic
pain for which the glial-modulated immune response (GMIR) is key. Understanding the
glial activation in pain pathways may well be key to reducing persistent pain,16 with
palmitoylethanolamide (PEA) which is an endogenous lipid modulator in animals and
human beings and has been evaluated since the 1970s as an anti-inflammatory and analgesic
drug in more than 30 clinical trials, in a total of ~6,00017 patients, including eight
clinical trials for nerve entrapment. In one pivotal, double-blind, placebo-controlled
trial in 636 sciatic pain patients, the number needed to treat (NNT) to reach 50%
pain reduction compared to baseline was NNT=1.5 after 3 weeks of treatment.18 This
emerging evidence is of interest as no drug interactions or troublesome side effects
have been described so far.
In addition, the emerging biology of pulsed radiofrequency neurotomies is unique in
that it provides pain relief without causing significant damage to nervous tissue,
with animal studies demonstrating modulation of pain transmission in the spinal nerves
and spinal cord by a range of mechanisms including modulating gene expression19 and
microglial neurotransmitters.20–22 These emerging concepts in the literature start
to provide biological mechanisms to the use of pulsed radiofrequency modalities for
people with spinal pain.
Decades worth of research outcomes suggests that knowledge and guidelines related
to both acute and chronic spinal pain are now available23,24 – certainly enough to
inform practice and the implementation of evidence-informed care services for persistent
spinal pain. New policy documents have emerged in Australia, for example, the Spinal
Pain Model of Care and the Framework for Chronic Pain,25,26 along with published recommendations
from recent systematic reviews. For example, exercise, tai chi, yoga, mindfulness-based
stress reduction and other psychological therapies, spinal manipulation and massage,
acupuncture, nonsteroidal anti-inflammatory drugs (NSAIDs; although less effective
than previously reported), duloxetine, tramadol and skeletal muscle relaxants (short-term
relief only) seem to have a positive role. Yet, commonly encountered treatments, such
as passive physical therapies (interferential therapy, short-wave diathermy, traction,
ultrasound, lumbar supports, taping, electrical muscle stimulations), opioids (the
evidence is very limited for their efficacy), paracetamol, benzodiazepines, systemic
corticosteroids, tricyclic and selective serotonin reuptake inhibitor (SSRI) antidepressants,
do not seem to contribute much to outcomes.27,28
It is fair to say that we have attended numerous seminars and discussions (such as
the working groups and forums in Western Australia [WA] that culminated in the WA
Framework for Persistent Pain [2016–2021]),26 all of which are saying much the same
things and consistently offering similar recommendations about chronic spinal pain
care. There is ample written about the contemporary approach and context of pain management,
such as the Royal Australian College of General Practitioners’ pain management contextual
statement.29 Therefore, the future of persistent pain management is less about doing
more research and producing more guidelines, although research continues to be important,
but rather about implementation of existing care frameworks and models of care30–32
with a view to obtaining better outcomes for patients at a reasonable cost. It is
very likely, indeed desirable, that care frameworks and models of care will evolve
and be updated every 5–6 years, so stakeholders should keep an eye out and keep themselves
informed as to how care services are changing.
The health care literature convincingly reports that coordinated, multidisciplinary
and multimodal care, at the right level, is desired to achieve the best possible outcomes
for patients and is very likely to be cost-effective.33 The challenge now is to have
persistent spinal pain fully acknowledged as a legitimate chronic condition by both
health care providers and policy makers/payers and have evidence-informed, cost-efficient
care delivered in the manner described in published frameworks and models of care.
Despite the complexity of spinal pain and its management, as with most chronic diseases,
the potential workforce and services can and must be made available with appropriate
attention, planning and leadership, with a view to improving accessibility to appropriate
care early in the development of the spinal pain condition. The consequences are a
large population of chronic pain sufferers, worsened by age-related comorbidities,
which will be a tremendous burden and cost to the health care system, not to mention
the personal suffering of the individual and their carers.
Getting access to the right care at the right time is critical, but the right multidisciplinary
team is currently the elusive goal of contemporary spinal pain management. In Australia,
waiting times for pain services and specialist appointment may run into many months,
if not longer, thereby missing the opportunity for timely treatment.34 The problem
does not lie with access to pain medication/analgesics per se; these may be prescribed
by general practitioners (GPs)/family physicians, indeed already too often or too
much,35 but rather with artful analgesic prescribing and coordinated multimodal treatments
within a multidisciplinary setting. We know that spinal pain, according to various
reports, such as from the Australian BEACH (Bettering the Evaluation and Care of Health)
project, is common and that analgesics for it are among two of the top five most commonly
prescribed medications.36 Upshur et al37 showed that 37.5% of adult appointments in
a typical GP’s week involved chronic pain complaints, comprising back pain (23.6%),
followed by joint pain (17.1%), headache (12.1%), generalized pain (7.8%) and neck
pain (7.5%). Indeed, the proposed approach and management for pain are eloquently
summarized in numerous papers directed at health care practitioners, such as by Wan38
and Goucke39 yet most doctors are dissatisfied with outcomes and uncomfortable managing
chronic pain.40 Clearly, there is a gap in care service which appears not to be related
to examination, diagnosis or analgesic prescribing, but due to “something else,” which
we believe is related to proper triage of persons with pain, which would include questionnaires
and assessment, and the access of these persons to the appropriate level of multidisciplinary
care at the soonest opportunity.
So, how may pain services be delivered in the future to comply with models of care
and frameworks while reconciling the challenges of a complex pain service, including
that of funding? The idea, of course, is to create a sustainable, comprehensive service
with sufficient incentive and reward for the participating workforce. To this end,
the coauthors agree that there is likely to be a mixed business model incorporating
both the private and public sectors, but on a more community and patient-centric basis,
with funds returned to front-line service delivery for integrated interprofessional
pain services. This approach would reduce middle management (reducing management costs)
and be subject to far less politics, as has been encountered with the poly- or super-clinic
concept, while still being able to collaborate with relevant local and state government
and nongovernment organizations. The “third way” ideology for the management of complex
spinal pain may have relevance, particularly when it comes to the funding/payment
for services. In theory, the “third-way” ideology attempts to graft the traditional
concerns about equality and social justice into an economic system based on free markets,
thereby implying a mix of public and private health care models. That implies the
use of both public and private funding to cover the expenses for care services, where
there are government funding or rebates for care services, but the patient themselves
also pays a portion of the costs.41,42 With a mixed-model business approach and using
contemporary models of care, future research should focus on exploring, creating and
testing pain care service approaches and methods, to determine those that fulfill
the criteria of modern evidence-based practice, these principles being: 1) the use
of the best available research evidence, 2) clinical and business experience/expertise,
3) stakeholder/consumer preference and access to care and, importantly, 4) the available
resources and funding. We strongly promote item 4 as an essential component of evidence-based
practice, often omitted in care frameworks and practice guidelines. Research will
continue to inform clinical practice by offering evidence from practice-based research
that test packages or models of care for spinal pain, alongside assessment of teamwork
and human dynamics encountered within service delivery.
These limitations of current care services for spinal pain are emphasized in a recently
published Model of Care for Spinal Pain and WA Framework for Persistent Pain (2016–2021),26
where the case for patient-centered, coordinated and collaborative approach to care
provision is offered. There are significant barriers to multidisciplinary, collaborative
working, such as professional “turf wars,” limited incentive and problems with funding,
but despite the difficulties, we believe that it can be performed and needs to be
performed, for the benefit of patients and also to more efficiently manage the burden
of chronic spinal pain on behalf of the health care system. An example of how collaborative
practice is emerging in Australia is via the patient-centered medical home (PCMH)
model, as described by Thistlethwaite43 and Kellerman,44 where health care practitioners
are colocated and collaborate to improve care delivery in primary care, while reducing
costs. This is not the only model of multidisciplinary working, and there are more
than one way to skin the proverbial cat, but it does show the way health care practitioners,
leadership, training and funding of care for chronic spinal pain, and other chronic
diseases, will need to change, with the characteristics of good care being accessibility,
quality care, safety, timely care and coordinated care. The complexity in chronic
spinal pain management, as with other chronic conditions, is not only about the appropriate
implementation of the individual parts of care but also ensuring that the triage,
coordination of care and the multidisciplinary approach works well. This takes planning,
commitment and leadership. For example, the colocation of health care practitioners
in the same building does not guarantee multidisciplinary or integrated team care
– there needs to be explicit consideration of human dynamics and the team process
for teamwork to succeed.45 Sound leadership provided by a champion of the service
would facilitate this teamwork approach.
So, how can colocated health care teams be set up to deliver optimal care? We suggest
that the process starts with motivated, energetic health care practitioners with an
interest in chronic pain management to take the reins and begin planning for such
community-based, primary care services. These motivated persons would draw upon their
own practice experience and obtain advice/support from local health care organizations,
such as Primary Health Networks46 and the Patient-Centered Primary Care Collaborative47
encountered in Australia, among others, to develop a business case and feasibility
of a local pain service. Grants or funding for community-based pain services are vague
with fluctuating commitment from government sources. Hence, community-based pain services
are likely to develop through private funding or pain practitioners developing their
own private practices that offer a broader range of services than currently offered.
Also, organizations like the Primary Care Networks, or even private/corporate health
care organizations, may be a source of funding or facilitation of pain services. We
do, however, caution against getting caught up in health care politics, as witnessed
with the UK Polyclinics48,49 and Australian Super Clinics44,50 which have received
a mixed reception, where the attempt at integrating community-based care services
has been negatively confounded by political influences.
In summary, we feel that there is already sufficient research evidence and recommendations
documented in published guidelines, frameworks and models of care to inform clinical
practice and the care of chronic spinal pain worldwide. The overt gap in care services
is not the availability of prescription medication or allied health services, but
rather the coordinated, multidisciplinary provision of care services by health care
practitioners with an interest and skill in pain management. The challenge of our
time is ensuring early access of patients with chronic spinal pain to care, coordinated
practitioner teamwork and the application of the correct level of care individualized
to the patient. On a positive note, this type of integrated service is emerging in
dedicated pain centers and community-based clinics, which will hopefully expand going
into the future. From here on, health care funders and medical insurers need to be
persuaded that the model of care provision for chronic spinal pain is cost-efficient
and cheaper than the current approaches.8,51
Interventional pain procedures: Needles, probes, catheters or stimulation leads are
used to pierce the skin and body parts, to reach a precise anatomical location to
deliver drugs to the targeted areas or modulate nerve transmission, for the diagnosis
or treatment of pain, either as a trial or a definitive procedure. This is usually
in conjunction with imaging that allows confirmation of anatomically correct positioning
of the needle, confirmation with radio-opaque contrast or fluid volume effect if using
ultrasound.
Diagnostic interventional pain procedures: Diagnostic procedures require a precisely
placed needle, through which local anesthetic (usually low volume) can be instilled
in the anatomical structure, or over the anatomical path of the sensory nerve relevant
to the proposed pain source that is being investigated. This is in conjunction with
imaging that allows confirmation of anatomically correct positioning of the needle,
confirmation with radio-opaque contrast or fluid volume effect if using ultrasound.
This allows reproducibility if a significant reduction in pain is achieved during
the local anesthetic phase. Placebo-controlled diagnostic blocks, or comparison between
duration of local anesthetic action, require repeated procedures and are the gold
standard. Diagnostic procedures aim to determine the relative contributions of anatomically
linked pain as people can have multiple inputs from multiple structures. Co-instillation
of corticosteroids and other adjuncts in some patients may prolong benefit, and in
these instances the procedure can be both diagnostic and therapeutic.
Therapeutic interventional pain procedures: Needles, probes, catheters and/or stimulation
leads are used to pierce the skin and body parts, to reach a precise anatomical location
to deliver drugs to the targeted areas or modulate nerve transmission, with the expectation
of pain relief for weeks, months or years. This is usually in conjunction with imaging
that allows confirmation of anatomically correct positioning of the needle, confirmation
with radio-opaque contrast or fluid volume effect if using ultrasound.