Positive oxidative stress in aging and aging-related disease tolerance ^☆

Abstract

It is now well established that reactive oxygen species (ROS), reactive nitrogen species (RNS), and a basal level of oxidative stress are essential for cell survival. It is also well known that while severe oxidative stress often leads to widespread oxidative damage and cell death, a moderate level of oxidative stress, induced by a variety of stressors, can yield great beneficial effects on adaptive cellular responses to pathological challenges in aging and aging-associated disease tolerance such as ischemia tolerance. Here in this review, I term this moderate level of oxidative stress as positive oxidative stress, which usually involves imprinting molecular signatures on lipids and proteins via formation of lipid peroxidation by-products and protein oxidation adducts. As ROS/RNS are short-lived molecules, these molecular signatures can thus execute the ultimate function of ROS/RNS. Representative examples of lipid peroxidation products and protein oxidation adducts are presented to illustrate the role of positive oxidative stress in a variety of pathological settings, demonstrating that positive oxidative stress could be a valuable prophylactic and/or therapeutic approach targeting aging and aging-associated diseases.

Graphical abstract

Highlights

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  Basal levels of ROS and RNS are essential for cell survival.

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  Severe oxidative stress and oxidative damage usually lead to cell death.

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  Positive oxidative stress can be induced by preconditioning and postconditioning.

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  Lipid- and protein oxidation can execute the effects of positive oxidative stress.

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  Positive oxidative stress can serve as a prophylactic or therapeutic approach.