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      Association of Noncognitive Life Skills With Mortality at Middle and Older Ages in England

      research-article
      , DSc 1 , , , PhD 1
      JAMA Network Open
      American Medical Association

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          Key Points

          Question

          Are greater noncognitive life skills associated with reduced mortality in older adults?

          Findings

          In this cohort study of 7850 adults aged 52 years and older followed up for approximately 7 years, the combination of conscientiousness, emotional stability, persistence, optimism, and sense of control was associated with reduced mortality independently of sociodemographic, health, and behavioral factors, but no single life skill explained the association.

          Meaning

          These findings suggest that higher levels of noncognitive life skills are associated with longer survival, suggesting that maintenance of these skills in later life is relevant to health.

          Abstract

          This cohort study examines the associations of noncognitive life skills, including conscientiousness, emotional stability, persistence, optimism and sense of control, with mortality in adults 52 years and older.

          Abstract

          Importance

          Noncognitive life skills are patterns of behavior, thoughts, and feelings that complement cognitive ability in promoting positive economic and educational outcomes. These positive attributes have been associated with favorable social and health outcomes at older ages, but their combined association with survival is not known.

          Objectives

          To evaluate the association of the combination of 5 noncognitive life skills with mortality, and to explore the role of sociodemographic, health, cognitive, and behavioral factors in explaining associations.

          Design, Setting, and Participants

          This cohort study used data from wave 5 of the English Longitudinal Study of Ageing, conducted in 2010. Participants included adults 52 years and older. Associations of scores on 5 noncognitive life skills, including conscientiousness, perseverance, emotional stability, optimism, and control, with all-cause mortality were analyzed for a mean (SD) of 7.2 (1.3) years. Data analyses were completed in November 2019.

          Exposures

          Response to wave 5 of the English Longitudinal Study of Ageing.

          Main Outcomes and Measures

          Noncognitive life skills scores, including conscientiousness, perseverance, emotional stability, optimism, and control, were measured by questionnaire. The main outcome was all-cause mortality, and the associations with noncognitive life skills scores were analyzed using Cox proportional hazards regressions models to estimate hazard ratios per 1-SD increase in score.

          Results

          A total of 7850 participants (mean [SD] age, 66.5 [9.0] years; 4333 [55.2%] women) were included. Combined life skill score was positively associated with survival, with a hazard ratio of 0.81 (95% CI, 0.72-0.90) per 1-SD increase in positive attributes after adjustment for age, sex, race/ethnicity, childhood socioeconomic status, educational attainment, baseline chronic disease, depressive symptoms, cognitive function, mobility impairment, social isolation, smoking, physical activity, alcohol intake, and fruit and vegetable consumption ( P < .001). Excluding deaths during 24 months after baseline as a check for reverse causation showed the same pattern (adjusted hazard ratio, 0.79; 95% CI, 0.70-0.89; P < .001). Associations were maintained after each life skill was omitted in turn from the aggregate score, indicating that no single positive attribute accounted for the protective association.

          Conclusions and Relevance

          These findings suggest that noncognitive life skills are associated with survival at older ages. Whether training and education programs could enhance these attributes and influence mortality risk is not known, but fostering and maintaining life skills may be important in later life.

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          Most cited references27

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          World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects.

          (2013)
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            Sensitivity Analysis in Observational Research: Introducing the E-Value.

            Sensitivity analysis is useful in assessing how robust an association is to potential unmeasured or uncontrolled confounding. This article introduces a new measure called the "E-value," which is related to the evidence for causality in observational studies that are potentially subject to confounding. The E-value is defined as the minimum strength of association, on the risk ratio scale, that an unmeasured confounder would need to have with both the treatment and the outcome to fully explain away a specific treatment-outcome association, conditional on the measured covariates. A large E-value implies that considerable unmeasured confounding would be needed to explain away an effect estimate. A small E-value implies little unmeasured confounding would be needed to explain away an effect estimate. The authors propose that in all observational studies intended to produce evidence for causality, the E-value be reported or some other sensitivity analysis be used. They suggest calculating the E-value for both the observed association estimate (after adjustments for measured confounders) and the limit of the confidence interval closest to the null. If this were to become standard practice, the ability of the scientific community to assess evidence from observational studies would improve considerably, and ultimately, science would be strengthened.
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              Social isolation, loneliness, and all-cause mortality in older men and women

              Both social isolation and loneliness are associated with increased mortality, but it is uncertain whether their effects are independent or whether loneliness represents the emotional pathway through which social isolation impairs health. We therefore assessed the extent to which the association between social isolation and mortality is mediated by loneliness. We assessed social isolation in terms of contact with family and friends and participation in civic organizations in 6,500 men and women aged 52 and older who took part in the English Longitudinal Study of Ageing in 2004-2005. A standard questionnaire measure of loneliness was administered also. We monitored all-cause mortality up to March 2012 (mean follow-up 7.25 y) and analyzed results using Cox proportional hazards regression. We found that mortality was higher among more socially isolated and more lonely participants. However, after adjusting statistically for demographic factors and baseline health, social isolation remained significantly associated with mortality (hazard ratio 1.26, 95% confidence interval, 1.08-1.48 for the top quintile of isolation), but loneliness did not (hazard ratio 0.92, 95% confidence interval, 0.78-1.09). The association of social isolation with mortality was unchanged when loneliness was included in the model. Both social isolation and loneliness were associated with increased mortality. However, the effect of loneliness was not independent of demographic characteristics or health problems and did not contribute to the risk associated with social isolation. Although both isolation and loneliness impair quality of life and well-being, efforts to reduce isolation are likely to be more relevant to mortality.
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                Author and article information

                Journal
                JAMA Netw Open
                JAMA Netw Open
                JAMA Netw Open
                JAMA Network Open
                American Medical Association
                2574-3805
                14 May 2020
                May 2020
                14 May 2020
                : 3
                : 5
                : e204808
                Affiliations
                [1 ]Department of Behavioural Science and Health, University College London, London, United Kingdom
                Author notes
                Article Information
                Accepted for Publication: March 8, 2020.
                Published: May 14, 2020. doi:10.1001/jamanetworkopen.2020.4808
                Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 Steptoe A et al. JAMA Network Open.
                Corresponding Author: Andrew Steptoe, DSc, Department of Behavioural Science and Health, University College London, 1-19, Torrington Place, London WC1E 6BT ( a.steptoe@ 123456ucl.ac.uk ).
                Author Contributions: Drs Steptoe and Jackson had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
                Concept and design: Steptoe.
                Acquisition, analysis, or interpretation of data: Both authors.
                Drafting of the manuscript: Steptoe.
                Critical revision of the manuscript for important intellectual content: Both authors.
                Statistical analysis: Both authors.
                Obtained funding: Steptoe.
                Conflict of Interest Disclosures: None reported.
                Funding/Support: The English Longitudinal Study of Ageing is administered by a team of researchers based at the University College London, NatCen Social Research, the Institute for Fiscal Studies, and the University of Manchester. Funding is provided by National Institute on Aging (R01AG017644; principal investigator: Dr Steptoe) and by a consortium of UK government departments coordinated by the National Institute for Health Research.
                Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
                Article
                zoi200232
                10.1001/jamanetworkopen.2020.4808
                7225907
                32407505
                4d29fb23-5287-475b-8092-f8ea89560d45
                Copyright 2020 Steptoe A et al. JAMA Network Open.

                This is an open access article distributed under the terms of the CC-BY License.

                History
                : 30 December 2019
                : 8 March 2020
                Categories
                Research
                Original Investigation
                Online Only
                Public Health

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