For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
3
views
8
references
 Top references
cited by
7
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      671
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Dupilumab‐associated head and neck dermatitis is associated with elevated pretreatment serum Malassezia‐specific IgE: a multicentre, prospective cohort study

      letter

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Dupilumab associated head and neck dermatitis is incompletely understood. This prospective multicentre prospective study identified baseline Malassezia‐specific IgE as associated with the development of Dupilumab associated head and neck dermatitis.

          Related collections

          Most cited references8

          • Record: found
          • Abstract: found
          • Article: not found

          Mechanisms of Dupilumab

          Hani Harb, Talal A Chatila (2019)
          The Th2 cytokines interleukin 4 (IL-4) and IL-13 and the heterodimeric IL-4 receptor (IL-4R) complexes that they interact with play a key role in the pathogenesis of allergic disorders. Dupilumab is a humanized IgG4 monoclonal antibody that targets the IL-4 receptor alpha chain (IL-4Rα), common to both IL-4R complexes: type 1 (IL-4Rα/γc; IL-4 specific) and type 2 (IL-4Rα/IL-13Rα1; IL-4 and IL-13 specific). In this review we detail the current state of knowledge of the different signaling pathways coupled to the IL-4R complexes, examine the possible mechanisms of Dupilumab action and survey its clinical efficacy in different allergic disorders. The development of Dupilumab and the widening spectrum of its clinical applications is relevant to the current emphasis on precision medicine approaches to the blockade of pathways involved in allergic diseases.
          Article 0 comments Cited 106 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found
            Is Open Access

            Clinical and histopathological characterization of paradoxical head and neck erythema in patients with atopic dermatitis treated with dupilumab: a case series

            L.E.M. de Wijs, N.T Nguyen, A.C.M. Kunkeler … (2019)
            Summary Dupilumab is the first biologic registered for the treatment of atopic dermatitis (AD). We report on seven patients with AD presenting with a paradoxical head and neck erythema that appeared 10–39 weeks after the start of dupilumab treatment. The patients presented with a relatively sharply demarcated, patchy erythema in the head and neck area that showed no or less scaling compared with their usual eczema. Only one patient experienced symptoms of itch and burning, although this was notably different from his pre‐existent facial AD. Except for a notable ‘red face’, eczema on other body parts had greatly improved in six of the seven patients, with a mean numerical rating scale for treatment satisfaction of 9 out of 10 at the time of biopsy. Treatment of the erythema with topical and systemic drugs was unsuccessful. Despite the presence of this erythema, none of our patients discontinued dupilumab treatment. Lesional skin biopsies showed an increased number of ectatic capillaries, and a perivascular lymphohistiocytic infiltration in all patients. In addition, epidermal hyperplasia with elongation of the rete ridges was observed in four patients, resembling a psoriasiform dermatitis. Additional immunohistochemical stainings revealed increased numbers of plasma cells, histiocytes and T lymphocytes. Interestingly, spongiosis was largely absent in all biopsies. We report on patients with AD treated with dupilumab developing a paradoxical erythema in a head and neck distribution. Both clinically and histopathologically we found a heterogeneous response, which was most suggestive of a drug‐induced skin reaction.
            Article 0 comments Cited 40 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              The role of Malassezia in atopic dermatitis affecting the head and neck of adults.

              Kamruz Darabi, Sarah Grim Hostetler, Mark A. Bechtel … (2009)
              Atopic dermatitis is a common chronic skin condition. A subset of patients with head and neck dermatitis may have a reaction to Malassezia flora fueling their disease. Although there are no documented differences in Malassezia species colonization, patients with head and neck atopic dermatitis are more likely to have positive skin prick test results and Malassezia-specific IgE compared with healthy control subjects and patients with atopy without head and neck dermatitis. There is no clear relationship with atopy patch testing. The reaction to Malassezia is likely related to both humoral- and cell-mediated immunity. Clinically, Malassezia allergy may be suspected in patients with atopic dermatitis and: (1) head and neck lesions; (2) exacerbations during adolescence or young adulthood; (3) severe lesions recalcitrant to conventional therapy; and (4) other atopic diseases. There is literature to suggest that these patients will benefit from a 1- to 2-month course of daily itraconazole or ketoconazole followed by long-term weekly treatment.
              Article 0 comments Cited 37 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                John W. Frew:
                ORCID: https://orcid.org/0000-0001-5042-3632
                john.frew@unsw.edu.au
                Journal
                Journal ID (nlm-ta): Br J Dermatol
                Journal ID (iso-abbrev): Br J Dermatol
                Journal ID (doi): 10.1111/(ISSN)1365-2133
                Journal ID (publisher-id): BJD
                Title: The British Journal of Dermatology
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Print): 0007-0963
                ISSN (Electronic): 1365-2133
                Publication date (Electronic): 19 April 2022
                Publication date (Print): June 2022
                Volume: 186
                Issue: 6 ( doiID: 10.1111/bjd.v186.6 )
                Pages: 1050-1052
                Affiliations
                [ 1 ] Department of Dermatology Liverpool Hospital Liverpool Sydney NSW Australia
                [ 2 ] University of New South Wales Sydney NSW Australia
                [ 3 ] Laboratory of Translational Cutaneous Medicine Ingham Institute of Applied Medical Research Liverpool Sydney NSW Australia
                Author notes
                [*] [* ] Correspondence: John W. Frew.

                Email: john.frew@ 123456unsw.edu.au

                Author information
                https://orcid.org/0000-0001-5042-3632
                Article
                Publisher ID: BJD21019 Other ID: BJD-2021-2639.R1
                DOI: 10.1111/bjd.21019
                PMC ID: 9322676
                PubMed ID: 35041759
                SO-VID: 4d4ab25b-e175-4174-b5e0-328c20ef889f
                Copyright © © 2022 The Authors. British Journal of Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists.
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

                History
                Date revision received : 29 December 2021
                Date received : 18 November 2021
                Date accepted : 15 January 2022
                Page count
                Figures: 2, Tables: 0, Pages: 1054, Words: 1665
                Categories
                Subject: Research Letter
                Subject: Correspondence
                Subject: Research Letters
                Custom metadata
                source-schema-version-number 2.0
                cover-date June 2022
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:6.1.7 mode:remove_FC converted:26.07.2022

                ScienceOpen disciplines: Dermatology
                Data availability:
                ScienceOpen disciplines: Dermatology

                Comments

                Comment on this article

                scite_

                Similar content671

                See all similar

                Cited by7

                See all cited by

                Most referenced authors80

                See all reference authors