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      Giant solitary trichoepithelioma

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          Adnexal tumors like giant solitary trichoepitheliomas are uncommon to most of us to permit a ready familiarity with them. Information regarding the genesis, clinical profile, behavior, and management options for this tumor is limited. There are 18 cases reported in the world literature till date. This review attempts to provide insight to this rare tumor. Our search included indexed literature from Pubmed, Directory of Open Access Journals, Health Inter Network Access to Research Initiative and Google databases in addition to standard dermatology texts. Giant solitary trichoepithelioma is a rare trichogenic tumor with potential for local recurrence. It has predilection for the older age, but may present at any age including at birth. It has close resemblance to basal cell carcinoma and other skin adnexal tumors - clinically, cytologically, and histologically. CD10, CD 34, PHLDA1 but not p75NTR are useful adjunct markers. Surgical excision is the standard treatment. Recurrence and possible transformation into BCC cautions follow up at regular intervals.

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          Most cited references 45

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          Rosai and Ackerman's Surgical Pathology

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            CD34 staining pattern distinguishes basal cell carcinoma from trichoepithelioma.

            Trichoepithelioma is a benign skin tumor with follicular differentiation, which sometimes is difficult to distinguish clinically and histologically from basal cell carcinoma. One of the most helpful differences is the histologic appearance of the stroma. CD34 is an antigen known to stain the spindle-shaped cells located around the middle portion of normal hair follicles. We have stained formalin-fixed, paraffin-embedded sections of 16 trichoepitheliomas and 19 basal cell carcinomas for CD34 (anti-HPCA-1, Becton Dickinson, San Jose, Calif) to detect differences in the staining pattern and to facilitate discrimination of these two types of tumors. The spindle-shaped cells surrounding the islands of trichoepithelioma cells were focally strongly positive for CD34. In all basal cell carcinomas, the spindle-shaped cells surrounding the nests of tumor cells were negative; in these areas only the blood vessels were positive with this antibody. CD34 staining pattern differentiates between trichoepithelioma and basal cell carcinoma. CD34 stain may be helpful in distinguishing between these two tumors on small punch biopsies or in difficult diagnostic cases.
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              Premalignant fibroepithelial tumors of skin.

               H Pinkus (1953)

                Author and article information

                South Asian J Cancer
                South Asian J Cancer
                South Asian Journal of Cancer
                Medknow Publications & Media Pvt Ltd (India )
                Jan-Mar 2015
                : 4
                : 1
                : 41-44
                Department of Surgery, DMWIMS, Wayanad, Kerala, India
                [1 ]Department of Surgery, JSS Medical College and Hospital, Mysore, India
                [2 ]Department of Surgery, Srinivasa Institute of Medical Science, Mangalore, Karnataka, India
                Author notes
                Correspondence to: Dr. Bhavuray Teli, E-mail: teli.bhavu@ 123456gmail.com
                Copyright: © South Asian Journal of Cancer

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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