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      Role of Hypothalamic Histaminergic Neurons in Mediation of ACTH and Beta-Endorphin Responses to LPS Endotoxin in vivo

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          Abstract

          The involvement of hypothalamic histaminergic neurons in the mediation of the ACTH and β-endorphin (β-END) response to lipopolysaccharide (LPS) endotoxin was investigated in conscious male rats. LPS stimulated the release of ACTH and β-END dose-dependently and increased the hypothalamic concentration of the histamine (HA) metabolite tele-methylhistamine significantly and that of HA slightly, indicating an increased turnover of neuronal HA. Pretreatment with the HA synthesis inhibitor α-fluoromethyl-histidine administered intracerebroventricularly (i.c.v.) or intraperitoneally (i.p.) inhibited the ACTH and β-END response to LPS about 60%, whereas i.p. administration of the H<sub>3</sub> receptor agonist R(α)methylHA, which inhibits HA synthesis and release, decreased the response about 50%. Pretreatment with the H<sub>1</sub> receptor antagonist mepyramine (67 µg × 2 i.c.v.) inhibited the hormone response to LPS about 50%, while pretreatment with equimolar doses of the H<sub>1</sub> receptor antagonists cimetidine (67 µg × 2 i.c.v.) or ranitidine (83 µg × 2 i.c.v.) had no effect on the LPS-induced release of ACTH and β-END. When the H<sub>1</sub> receptor antagonists mepyramine and cetirizine were administered i.p. in doses (10 mg/kg) which penetrate the blood-brain barrier the hormone response to LPS was inhibited 50% and 30%, respectively. Administered i.p. the H<sub>2</sub> receptor antagonists had no effect on the hormone response to LPS. We conclude that hypothalamic histaminergic neurons in rats are involved in the mediation of the ACTH and β-END response to LPS stimulation via activation of central postsynaptic H<sub>1</sub> receptors.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1994
          1994
          09 April 2008
          : 60
          : 3
          : 243-251
          Affiliations
          aDepartment of Medical Physiology, Division of Endocrinology and Metabolism, The Panum Institute, and bDepartment of Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Denmark; cUnité de Neurobiologie et Pharmacologie, Unité 109, Institut National de la Santé et de la Recherche Médicale, Centre Paul Broca, Paris, France
          Article
          126757 Neuroendocrinology 1994;60:243–251
          10.1159/000126757
          7969782
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Corticotropin Regulation and Corticoid Feedback

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