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      Metoclopramide Increases Plasma but Not Cerebrospinal Fluid Vasopressin Levels in Man: Study in Hydrocephalic Patients

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          Arginine vasopressin (AVP) concentrations were determined in plasma and in cerebrospinal fluid (CSF) in 8 adult male patients suffering from hydrocephalus of various etiologies, before and after intravenous administration of 10 mg metoclopramide. Metoclopramide was able to increase the plasma (2.6 ± 0.2 ng/l in basal conditions and 6.1 ± 0.6 ng/l at 30 min) but not the CSF AVP levels. The results suggest that the neurons which secrete AVP into the CSF may be functionally different from those secreting into the peripheral circulation.

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          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 35
          : 6
          : 239-241
          Departments of aInternal Medicine, bAnesthesiology and cNeurosurgery, University of Genoa, Italy
          181912 Horm Res 1991;35:239–241
          © 1991 S. Karger AG, Basel

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