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      Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review

      review-article
      Author(s): 1 , , 1
      Publication date (Electronic):
      Journal: Comparative Hepatology
      Publisher: BioMed Central

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          Abstract

          This review provides a detailed overview of the current state of knowledge about the ultrastructure and dynamics of liver sinusoidal endothelial fenestrae. Various aspects of liver sinusoidal endothelial fenestrae regarding their structure, origin, species specificity, dynamics and formation will be explored. In addition, the role of liver sinusoidal endothelial fenestrae in relation to lipoprotein metabolism, fibrosis and cancer will be approached.

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          Most cited references127

          • Record: found
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          An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids.

          E Wisse (1970)
          Article 0 comments Cited 90 times – based on 0 reviews     Review now
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            The morphology of cirrhosis. Recommendations on definition, nomenclature, and classification by a working group sponsored by the World Health Organization.

            Melinda Anthony, L Sobin, P. Scheuer … (1978)
            This memorandum provides guidelines on the definition, nomenclature, and classification of cirrhosis, chronic hepatitis, and hepatic fibrosis. These are considered according to morphological characteristics and aetiology. It is hoped that this system will serve as a standard for diagnostic, research, and epidemiological purposes. The relationship of cirrhosis to liver cell carcinoma is briefly discussed and the possible morphological markers of an increased risk of malignancy are defined.
            Article 0 comments Cited 65 times – based on 0 reviews     Review now
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              Lipoproteins and the liver sieve: the role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis.

              Alasdair R Fraser, Kyle Dobbs, Brooke G. Rogers (1995)
              The liver sieve, formed by the fenestrated hepatic sinusoidal endothelium, is a dynamic biofilter separating the hepatic blood from the plasma within the space of Disse. It filters macromolecules of differing sizes, especially lipoproteins. More specifically, it acts as a barrier to the large triglyceride-rich parent chylomicrons, while permitting the smaller triglyceride-depleted but cholesterol- and retinol-rich remnants to enter the space of Disse. There the remnants contact specific receptor sites on the hepatocyte microvilli. Thus, the liver sieve is the first site of hepatic selection and consequent metabolism of dietary cholesterol and fat-soluble vitamins, as well as rejection of dietary triglycerides. Therefore, perturbations of the porosity of the sieve, whether from changes in size, number of fenestrae, or composition of the underlying extracellular matrix within the space of Disse, will have a profound influence on the metabolism of lipoproteins. This disturbance of the homeostasis of lipids, including fat-soluble vitamins and cholesterol, as well as other macromolecules, may tilt the balance between health and disease in a variety of organs and tissues, such as the liver, kidney and arteries.
              Article 0 comments Cited 41 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Comp Hepatol
                Title: Comparative Hepatology
                Publisher: BioMed Central (London )
                ISSN (Electronic): 1476-5926
                Publication date Collection: 2002
                Publication date (Electronic): 23 August 2002
                Volume: 1
                Page: 1
                Affiliations
                [1 ]Laboratory for Cell Biology and Histology, Free University of Brussels (VUB), Laarbeeklaan 103, 1090 Brussels-Jette, Belgium
                Article
                Publisher ID: 1476-5926-1-1
                DOI: 10.1186/1476-5926-1-1
                PMC ID: 131011
                PubMed ID: 12437787
                SO-VID: 501d9262-09ac-439a-8d13-9d094a1d36c6
                Copyright © Copyright © 2002 Braet and Wisse; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
                History
                Date received : 6 August 2002
                Date accepted : 23 August 2002
                Categories
                Subject: Review

                ScienceOpen disciplines: Gastroenterology & Hepatology
                Data availability:
                ScienceOpen disciplines: Gastroenterology & Hepatology

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