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      Mechanical circulatory support in heart failure

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          Abstract

          The increasing number of end-stage heart failure patients eligible for heart transplant and the disproportionately low number of donor hearts have led to increased interest in ventricular assist devices (VAD). These devices can be used as a bridge to decision, bridge to recovery, or bridge to candidacy. The main advantage of mechanical circulatory support (MCS) is the improvement of organ perfusion and function, which leads to better quality of life and survival. The MCS can also be used as a destination therapy in end-stage heart failure patients who are not eligible for heart transplant. It should be remembered that, despite the tangible benefits, VAD implantation may also be associated with the risk of serious complications, such as bleeding, infection, arrhythmias, blood clots, right ventricular failure, and cardiovascular events. This study presents an up-to-date overview of the current knowledge on the role of MCS in modern medicine.

          Translated abstract

          Wzrastająca liczba chorych ze schyłkową niewydolnością serca ( heart failure – HF) zakwalifikowanych do transplantacji tego narządu i jednocześnie nieproporcjonalnie mała liczba dawców serca stanowią przyczynę zwiększonego zainteresowania urządzeniami służącymi do mechanicznego wspomagania krążenia ( ventricular assist device – VAD). Zadaniem tych urządzeń jest leczenie pomostowe do czasu podjęcia decyzji, poprawy lub też do momentu, kiedy chory stanie się kandydatem do przeszczepienia serca. Zasadniczą korzyścią z zastosowania VAD jest poprawa perfuzji i funkcji wszystkich narządów, czego skutkiem jest poprawa jakości życia i rokowania chorych. Dzięki temu VAD może być również leczeniem docelowym u chorych z krańcową HF, którzy nie kwalifikują się do transplantacji serca. Należy pamiętać, że oprócz wymiernych korzyści, wszczepienie VAD może się wiązać również z ryzykiem wystąpienia poważnych powikłań, takich jak krwawienia, zakażenia, arytmie, zakrzepy, niewydolność prawej komory oraz incydenty sercowo-naczyniowe. W artykule przedstawiono przegląd dotychczasowej wiedzy na temat roli mechanicznego wspomagania krążenia we współczesnej medycynie.

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          Most cited references32

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          Sixth INTERMACS annual report: a 10,000-patient database.

          The sixth annual report of the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) summarizes the first 8 years of patient enrollment. The analysis is based on data from >10,000 patients and updates demographics, survival, adverse events and risk factors. Among patients with continuous-flow pumps, actuarial survival continues to be 80% at 1 year and 70% at 2 years. The report features a comparison of two eras of continuous-flow durable devices in the USA in terms of device strategy, patient profiles, adverse event burden, survival and quality of life. Copyright © 2014 International Society for Heart and Lung Transplantation. All rights reserved.
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            An analysis of pump thrombus events in patients in the HeartWare ADVANCE bridge to transplant and continued access protocol trial.

            The HeartWare left ventricular assist device (HVAD, HeartWare Inc, Framingham, MA) is the first implantable centrifugal continuous-flow pump approved for use as a bridge to transplantation. An infrequent but serious adverse event of LVAD support is thrombus ingestion or formation in the pump. In this study, we analyze the incidence of pump thrombus, evaluate the comparative effectiveness of various treatment strategies, and examine factors pre-disposing to the development of pump thrombus.
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              Bleeding and thrombosis in patients with continuous-flow ventricular assist devices.

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                Author and article information

                Journal
                Kardiochir Torakochirurgia Pol
                Kardiochir Torakochirurgia Pol
                KITP
                Kardiochirurgia i Torakochirurgia Polska = Polish Journal of Cardio-Thoracic Surgery
                Termedia Publishing House
                1731-5530
                1897-4252
                30 June 2016
                June 2016
                : 13
                : 2
                : 130-134
                Affiliations
                [1 ]3 rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland
                [2 ]Student Scientific Society, 3 rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland
                Author notes
                Address for correspondence: Assoc. Prof. Bożena Szyguła-Jurkiewicz, 3 rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, 9 Curie-Skłodowskiej St, 41-800 Zabrze, Poland. phone: +48 60 410 299. e-mail: centrala4@ 123456wp.pl
                Article
                27922
                10.5114/kitp.2016.61046
                4971267
                27516785
                514d9a4e-dfe4-403c-9258-ac3a9739d614
                Copyright © 2016 Polish Society of Cardiothoracic Surgeons (Polskie Towarzystwo KardioTorakochirurgów) and the editors of the Polish Journal of Cardio-Thoracic Surgery (Kardiochirurgia i Torakochirurgia Polska)

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

                History
                : 12 March 2016
                : 13 May 2016
                Categories
                Review Paper

                mechanical circulatory support,heart failure
                mechanical circulatory support, heart failure

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